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Effects of the ancillary ligands of polypyridyl cobalt(II) complexes on pH-induced spectral properties and DNA binding properties

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Abstract

Two new Co(II) complexes [Co(ipH)2(bdipH)]2+ and [Co(8-HQ)2(bdipH)] (ipH = imidazo[4,5-f][1,10]phenanthroline, bdipH = 2-(benzo[d][1,3]dioxol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthroline, 8-HQ = 8-hydroxyquinoline) were synthesized and characterized in detail by elemental analysis, IR, and UV–Vis spectroscopic techniques. The effects of pH on the UV–Vis absorption and emission spectra of the complex were studied. The interaction of the two complexes with calf thymus DNA was explored by using viscosity measurements, electronic absorption titration, competitive binding experiments, and cyclic voltammetry. The experimental results show that complex [Co(ipH)2(bdipH)]2+ exhibits pH-sensitive emission, the two complexes can bind to DNA in an intercalation mode, and the DNA binding affinity of complex [Co(ipH)2(bdipH)]2+ (K b = 2.11 × 105 M−1) is greater than that of complex [Co(8-HQ)2(bdipH)] (K b = 1.76 × 105 M−1). The results show that the size and shape of the ancillary ligand have significant effects on the binding affinity of DNA and complexes.

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Authors and Affiliations

  1. College of Chemistry, Xiangtan University, Xiangtan, 411105, People’s Republic of China

    Xian W. Huang, Wen T. Zhu, Jia C. Zhang & Guo J. Su

  2. Universtar Science & Technology (Shenzhen) Co., Ltd., Shenzhen, People’s Republic of China

    Xian W. Huang

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  1. Xian W. Huang
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  2. Wen T. Zhu
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  3. Jia C. Zhang
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Correspondence to Guo J. Su.

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Huang, X.W., Zhu, W.T., Zhang, J.C. et al. Effects of the ancillary ligands of polypyridyl cobalt(II) complexes on pH-induced spectral properties and DNA binding properties. Monatsh Chem 143, 101–107 (2012). https://doi.org/10.1007/s00706-011-0624-1

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  • DOI: https://doi.org/10.1007/s00706-011-0624-1

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