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Solvent-free synthesis and antibacterial studies of some quinolinones

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Abstract

Solvent-free, microwave-induced condensation of 2-aminoaryl alkyl ketones and ethyl 3-oxobutanoate in the presence of amberlite Na sr1L gave quinolinones in high yield when compared to other catalysts. Further, N-alkylation of the quinolinones was carried out effectively with various halides using amberlite Na sr1L. An N-alkylated quinolinone exhibited enhanced activities against B. subtilis, E. coli, and P. aeruginosa, similar to standard drug ampicillin. Two compounds showed effective activity against S. aureus, and one resulted in moderate activity against E. coli.

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Acknowledgments

The authors thank VIT University Management for their generous support and other facilities.

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Authors and Affiliations

  1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, India

    Radhakrishnan Subashini & Fazlur-Rahman Nawaz Khan

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  1. Radhakrishnan Subashini
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  2. Fazlur-Rahman Nawaz Khan
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Correspondence to Fazlur-Rahman Nawaz Khan.

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Subashini, R., Khan, FR.N. Solvent-free synthesis and antibacterial studies of some quinolinones. Monatsh Chem 143, 485–489 (2012). https://doi.org/10.1007/s00706-011-0608-1

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  • DOI: https://doi.org/10.1007/s00706-011-0608-1

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