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A convenient synthesis of the immunosuppressive agent FTY720

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Abstract

This paper describes a practical synthetic approach to preparation of an immunosuppressant, FTY720. The key steps involve an iron-catalyzed cross-coupling reaction and a Wittig reaction. The advantages of this synthesis include readily available starting materials, inexpensive reagents, simple operations and good yields.

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Acknowledgments

We gratefully acknowledge financial support for new century excellent talents in university (NCET). We also thank Laboratory of Organic Functional Molecules, the Sino–French Institute of ECNU for support.

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Authors and Affiliations

  1. Department of Chemistry, East China Normal University, Shanghai, 200062, People’s Republic of China

    Xiangjun Feng, Yuhua Mei, Yu Luo & Wei Lu

Authors
  1. Xiangjun Feng
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  2. Yuhua Mei
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  3. Yu Luo
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  4. Wei Lu
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Correspondence to Yu Luo.

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Feng, X., Mei, Y., Luo, Y. et al. A convenient synthesis of the immunosuppressive agent FTY720. Monatsh Chem 143, 161–164 (2012). https://doi.org/10.1007/s00706-011-0582-7

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  • DOI: https://doi.org/10.1007/s00706-011-0582-7

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