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Sulfamic-acid-catalyzed simple and efficient synthesis of 4-aryl-3-methyl-1-phenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-diones under solvent-free conditions

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Abstract

An efficient synthesis of 4-aryl-3-methyl-1-phenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-diones from the three-component condensation reaction of 3-methyl-1-phenyl-1H-pyrazol-5-amine, aromatic aldehydes, and 2-hydroxy-1,4-naphthoquinone under solvent-free conditions in good to excellent yields and short reaction times using sulfamic acid as heterogeneous acid catalyst has been investigated.

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Acknowledgments

We are pleased to acknowledge the financial support from Xinxiang Medical University.

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Authors and Affiliations

  1. School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, People’s Republic of China

    Liqiang Wu, Suying Ma, Fulin Yan & Chunguang Yang

Authors
  1. Liqiang Wu
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  2. Suying Ma
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  3. Fulin Yan
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  4. Chunguang Yang
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Correspondence to Liqiang Wu.

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Wu, L., Ma, S., Yan, F. et al. Sulfamic-acid-catalyzed simple and efficient synthesis of 4-aryl-3-methyl-1-phenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-diones under solvent-free conditions. Monatsh Chem 141, 565–568 (2010). https://doi.org/10.1007/s00706-010-0282-8

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  • DOI: https://doi.org/10.1007/s00706-010-0282-8

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