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DNA combining and photocleaving properties of photosensitizer-encapsulated silica nanoparticles

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Abstract

Based on theoretical predictions, water-soluble silica nanoparticle encapsulated hypocrellin A (HA) was prepared, and its photosensitization activity was evaluated. The encapsulated HA showed not only very good water solubility, but also much stronger singlet oxygen generation ability than free HA. Investigations on binding interactions with DNA showed promising results as well. These findings suggest that HA carrier can exert photodynamic action via photosensitization.

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Acknowledgments

We are grateful to the National Natural Science Foundation of China (no. 20603018) and the Ministry of Education key project of China (no. 208047) for financial support.

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Authors and Affiliations

  1. Jiangsu Key Laboratory Biofunctional Materials, Analysis and Testing Center, Nanjing Normal University, Nanjing, People’s Republic of China

    Lin Zhou, Shao Hua Wei, Yu Ying Feng & Ji Hong Zhou

  2. Department of Complex Presection of CMM, China Pharmaceutical University, Nanjing, People’s Republic of China

    Lin Zhou, Ji Hua Liu & Bo Yang Yu

Authors
  1. Lin Zhou
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  2. Ji Hua Liu
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  3. Shao Hua Wei
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  4. Yu Ying Feng
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  5. Ji Hong Zhou
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  6. Bo Yang Yu
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Corresponding authors

Correspondence to Ji Hong Zhou or Bo Yang Yu.

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Zhou, L., Liu, J.H., Wei, S.H. et al. DNA combining and photocleaving properties of photosensitizer-encapsulated silica nanoparticles. Monatsh Chem 140, 1167–1170 (2009). https://doi.org/10.1007/s00706-009-0169-8

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  • DOI: https://doi.org/10.1007/s00706-009-0169-8

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