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A carbohydrate-linked hypericinic photosensitizing agent

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Abstract

With respect to an enhanced solubility under physiological conditions, a carbohydrate-containing hypericin-based second-generation photosensitizer was prepared. Its photochemical properties were tested by means of the light-sensitized destruction of bilirubin IXα to be even better than those of the parent compound hypericin. Investigations on binding-interactions with DNA showed promising results as well.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Joachim Zuschrader, Wolfgang Schöfberger & Heinz Falk

Authors
  1. Joachim Zuschrader
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  2. Wolfgang Schöfberger
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  3. Heinz Falk
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Corresponding author

Correspondence to Heinz Falk.

Additional information

Correspondence: Heinz Falk, Institute of Organic Chemistry, Johannes Kepler University, Altenbergerstraße 69, 4040 Linz, Austria, Europe.

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Zuschrader, J., Schöfberger, W. & Falk, H. A carbohydrate-linked hypericinic photosensitizing agent. Monatsh Chem 139, 1387–1390 (2008). https://doi.org/10.1007/s00706-008-0928-y

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  • DOI: https://doi.org/10.1007/s00706-008-0928-y

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