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Novel cationic conjugates of chlorin e6 with galactose fragments: synthesis and evaluation of photodynamic activity

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Chemistry of Heterocyclic Compounds Aims and scope

Water-soluble chlorin e6 cationic derivatives with one and two galactose fragments at the quaternized nitrogen atom were synthesized, and the dark and photoinduced cytotoxicity of the obtained compounds was evaluated.

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The work was financially supported by the Ministry of Science and Higher Education of the Russian Federation. State Assignment No. 122040600073-3 in the Institute of Chemistry of the Federal Research Center “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences. State Assignment No. 122040600024-5 in the Institute of Biology of the Federal Research Center “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences.

The synthesized compounds were analyzed using the equipment of the Center for Collective Use “Chemistry” at the Institute of Chemistry of the Federal Research Center “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences (Syktyvkar). The photodynamic activity was evaluated using the equipment of the Center for Collective Use “Molecular Biology” at the Institute of Biology of the Federal Research Center “Komi Scientific Centre”, Ural Branch of the Russian Academy of Sciences (Syktyvkar).

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 48 Pervomayskaya St., Syktyvkar, 167000, Russia

    Marina V. Mal’shakova & Dmitry V. Belykh

  2. Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 28 Kommunisticheskaya St., Syktyvkar, 167000, Russia

    Yana I. Pylina

Authors
  1. Marina V. Mal’shakova
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  2. Yana I. Pylina
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  3. Dmitry V. Belykh
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Corresponding author

Correspondence to Marina V. Mal’shakova.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(9/10), 703–708

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Mal’shakova, M.V., Pylina, Y.I. & Belykh, D.V. Novel cationic conjugates of chlorin e6 with galactose fragments: synthesis and evaluation of photodynamic activity. Chem Heterocycl Comp 59, 703–708 (2023). https://doi.org/10.1007/s10593-023-03257-0

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