Abstract
Two simple and sensitive spectrophotometric methods were developed for the determination of olanzapine (OLZ) based on its oxidation with potassium iodate in a sulfuric acid medium to produce an intense violet-colored species exhibiting a maximum absorbance at 537 nm. The initial rate of formation and the maximum absorbance of the violet-colored oxidized product were monitored, in the first and second methods. The various experimental parameters affecting the rate of development and stability of the oxidized product were carefully studied and optimized. Beer’s law was obeyed up to 4.0 and 7.0 μg cm−3 OLZ with correlation coefficients of 0.998 and 0.996 (n = 6) and detection limits of 0.1 and 0.15 μg cm−3, for the initial rate and maximum absorbance methods. The proposed methods were conveniently applied to the determination of OLZ in its dosage forms and in spiked serum samples.
Similar content being viewed by others
References
WW Shen (1999) Ann Clin Psychiatry 11 145 Occurrence Handle1:STN:280:DyaK1MvgvFymsw%3D%3D
K Kassahun E Mattiuz E Nyhart SuffixJr B Obermeyer T Gillespie A Murphy RM Goodwin D Tuper JT Callaghan L Lemberger (1997) Drug Metabol Dispos 25 81 Occurrence Handle1:CAS:528:DyaK2sXmtlymsw%3D%3D
BJ Ring J Callow TJ Lindsay T Gillespie LK Roskos BJ Cerimele SP Swanson MA Hamman SA Wrighton (1996) J Pharmacol Exp Therap 276 658 Occurrence Handle1:CAS:528:DyaK28XhtFakt7o%3D
J Bickeboeller-Friedrich HH Maurer (2001) Ther Drug Monit 23 61 Occurrence Handle10.1097/00007691-200102000-00012 Occurrence Handle1:CAS:528:DC%2BD3MXht1WltLg%3D
AJ Jenkins KM Sarconi HN Raaf (1998) J Anal Toxicol 22 605 Occurrence Handle1:CAS:528:DyaK1cXnslyksr0%3D
S Hillaert L Snoeck WV Bossche (2004) J Chromatogr A 1033 357 Occurrence Handle10.1016/j.chroma.2004.01.057 Occurrence Handle1:CAS:528:DC%2BD2cXhvFWku7g%3D
V Pucci MA Raggi E Kenndler (2000) J Liq Chromatogr Rel Technol 23 25 Occurrence Handle10.1081/JLC-100101433 Occurrence Handle1:CAS:528:DC%2BD3cXhtVWjt70%3D
ZL Zhou X Li KY Li ZH Xie ZN Cheng WX Peng F Wang RH Zhu HD Li (2004) J Chromatogr B 802 257 Occurrence Handle10.1016/j.jchromb.2003.11.037 Occurrence Handle1:CAS:528:DC%2BD2cXhslSrsbk%3D
A Pelander I Ojanpera S Laks I Rasanen E Vuori (2003) Anal Chem 75 5710 Occurrence Handle10.1021/ac030162o Occurrence Handle1:CAS:528:DC%2BD3sXnsVOisbY%3D
G Gervasini S Vizcaino AG Herraiz J Benitez JA Carrillo (2003) Clin Chem 49 2088 Occurrence Handle10.1373/clinchem.2003.022517 Occurrence Handle1:CAS:528:DC%2BD3sXpt1yntL8%3D
D Thieme H Sachs (2003) Anal Chim Acta 492 171 Occurrence Handle10.1016/S0003-2670(03)00563-4 Occurrence Handle1:CAS:528:DC%2BD3sXntVyjurY%3D
M Berna B Ackermann K Ruterbories S Glass (2002) J Chromatogr B 767 163 Occurrence Handle10.1016/S0378-4347(01)00548-5 Occurrence Handle1:CAS:528:DC%2BD38XhsFahsb8%3D
K Titier S Bouchet F Pehourcq N Moore M Molimard (2003) J Chromatogr B 788 179 Occurrence Handle10.1016/S1570-0232(02)01003-6 Occurrence Handle1:CAS:528:DC%2BD3sXjtlymtbg%3D
LJ Dusci LP Hackett LM Fellows KF Ilett (2002) J Chromatogr B 773 191 Occurrence Handle10.1016/S1570-0232(02)00164-2 Occurrence Handle1:CAS:528:DC%2BD38Xlt1Siurc%3D
DW Boulton JS Markowitz CL DeVane (2001) J Chromatogr B 759 319 Occurrence Handle10.1016/S0378-4347(01)00240-7 Occurrence Handle1:CAS:528:DC%2BD3MXkvVent78%3D
MA Raggi G Casamenti R Mandrioli G Izzo E Kenndler (2000) J Pharm Biomed Anal 23 973 Occurrence Handle10.1016/S0731-7085(00)00382-4 Occurrence Handle1:CAS:528:DC%2BD3cXot1yhtr0%3D
C Sabbioni MA Saracino R Mandrioli L Albers G Boncompagni MA Raggi (2004) Anal Chim Acta 516 111 Occurrence Handle10.1016/j.aca.2004.04.031 Occurrence Handle1:CAS:528:DC%2BD2cXkvFyqsLg%3D
MA Raggi R Mandrioli C Sabbioni N Ghedini S Fanali V Volterra (2001) Chromatographia 54 203 Occurrence Handle10.1007/BF02492246 Occurrence Handle1:CAS:528:DC%2BD3MXmvVyluro%3D
JQ Bao BD Potts (2001) J Chromatogr B 752 61 Occurrence Handle10.1016/S0378-4347(00)00518-1 Occurrence Handle1:CAS:528:DC%2BD3MXhtFars78%3D
A Jasinska E Nalewajko (2004) Anal Chim Acta 508 165 Occurrence Handle10.1016/j.aca.2003.11.069 Occurrence Handle1:CAS:528:DC%2BD2cXhvV2nt7c%3D
D Perez-Bendito M Silva (1988) Kinetic Methods in Analytical Chemistry Ellis Horwood Chichester
AA Mohamed (2001) Monatsh Chem 132 919 Occurrence Handle10.1007/s007060170055 Occurrence Handle1:CAS:528:DC%2BD3MXntlSht74%3D
AT Mubarak AA Mohamed KF Fawy AS Al-Shihry (2007) Microchim Acta 157 99 Occurrence Handle10.1007/s00604-006-0661-3 Occurrence Handle1:CAS:528:DC%2BD2sXlsFOjtg%3D%3D
J Inczedy T Lengyel AM Ure (1998) IUPAC Compendium of Analytical Nomenclature: Definitive Rules Blackwell Science Inc. Boston
Author information
Authors and Affiliations
Corresponding author
Additional information
Correspondence: Ashraf A. Mohamed, Department of Chemistry, Faculty of Science, King Faisal University, P.O. Box 1759, Al-Hassa-31982, Saudi Arabia.
Rights and permissions
About this article
Cite this article
Mohamed, A. Kinetic and maximum-absorbance spectrophotometric methods for the determination of olanzapine. Monatsh Chem 139, 1005–1010 (2008). https://doi.org/10.1007/s00706-008-0894-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00706-008-0894-4