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Ammonium chloride catalyzed one-pot synthesis of imidazo[1,2-a]pyridines

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Abstract

Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot, three-component Groebke condensation reactions of aldehydes, isocyanides, and 2-aminopyridines or 2-aminopyrimidines in methanol to afford the corresponding imidazo[1,2-a]pyridines in high yields at room temperature.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Beheshti University, Tehran, Iran

    Ahmad Shaabani, Fahimeh Rezazadeh & Ebrahim Soleimani

Authors
  1. Ahmad Shaabani
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  2. Fahimeh Rezazadeh
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  3. Ebrahim Soleimani
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Corresponding author

Correspondence to Ahmad Shaabani.

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Correspondence: Ahmad Shaabani, Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran.

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Shaabani, A., Rezazadeh, F. & Soleimani, E. Ammonium chloride catalyzed one-pot synthesis of imidazo[1,2-a]pyridines. Monatsh Chem 139, 931–933 (2008). https://doi.org/10.1007/s00706-008-0872-x

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  • DOI: https://doi.org/10.1007/s00706-008-0872-x

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