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Electrospray mass spectrometric studies of a potential antitumor drug and its analogous platinum(II) and platinum(IV) complexes with the ethylenediamine-N,N′-di-3-propanoato ligand and its dibutyl ester

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Abstract

The electrospray mass spectrometric (ESI–MS) behavior of the complexes trans-dichloro(ethylenediamine-N,N′-di-3-propionato)platinum(IV), trans-dibromo(ethylenediamine-N,N′-di-3-propionato)platinum(IV), dichloro(ethylenediamine-N,N′-di-3-propionic acid)platinum(II), tetrachloro(O,O′-di-n-butyl-ethylenediamine-N,N′-di-3-propanoate)platinum(IV), chlorotribromo(O,O′-di-n-butyl-ethylenediamine-N,N′-di-3-propanoate)platinum(IV), and dichloro(O,O′-di-n-butyl-ethylenediamine-N,N′-di-3-propanoate)platinum(II), with the formulae trans-[PtCl2(eddp)] (1), trans-[PtBr2(eddp)] (2), [PtCl2(H2eddp)] (3), [PtCl4(Bu2eddp)] (4), [PtBr3Cl(Bu2eddp)] (5), and [PtCl2(Bu2eddp)]·H2O (6), is reported. The deprotonated molecular ions or halide adducts are usually observed. ESI–MS data demonstrate the usefulness of the method for efficient characterization of metal complexes in solution.

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Acknowledgments

The authors are grateful to the Ministry of Science and Technological Developments of the Republic of Serbia for financial support (Projects #142010 and #142002).

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Authors and Affiliations

  1. Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, Studentski trg 12-16, 11000, Belgrade, Serbia

    Goran N. Kaluđerović

  2. Faculty of Technology and Metallurgy, Karnegijeva 4, 11000, Belgrade, Serbia

    Tanja M. Vasiljević & Mila D. Laušević

  3. Faculty of Specific Education, Zagazig University, Zagazig, Egypt

    Akmal S. Gaballa

  4. Faculty of Chemistry, University of Belgrade, Studentski trg 12, P.O. Box 158, 11000, Belgrade, Serbia

    Tibor J. Sabo

Authors
  1. Goran N. Kaluđerović
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  2. Tanja M. Vasiljević
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  3. Mila D. Laušević
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  4. Akmal S. Gaballa
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  5. Tibor J. Sabo
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Correspondence to Goran N. Kaluđerović or Tibor J. Sabo.

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Kaluđerović, G.N., Vasiljević, T.M., Laušević, M.D. et al. Electrospray mass spectrometric studies of a potential antitumor drug and its analogous platinum(II) and platinum(IV) complexes with the ethylenediamine-N,N′-di-3-propanoato ligand and its dibutyl ester. Monatsh Chem 140, 553–557 (2009). https://doi.org/10.1007/s00706-008-0088-0

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  • DOI: https://doi.org/10.1007/s00706-008-0088-0

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