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Acyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes

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Abstract

5-Amino-2-azabicyclo[3.2.2]nonanes possess activity against the causative organisms of Human African trypanosomiasis and Malaria tropica. Their newly prepared N-acyl derivatives were inactive against Trypanosoma b. rhodesiense, but some of them showed good antiplasmodial activity against a multiresistant strain of Plasmodium falciparum. The results are compared to the activities of the N-unsubstituted compounds and N-sulfonyl analogues. The diastereomeric character of the formed amides was elucidated by NMR spectroscopy.

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria

    Robert Weis & Werner Seebacher

  2. Swiss Tropical Institute, Basel, Switzerland

    Marcel Kaiser & Reto Brun

  3. Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria

    Robert Saf

Authors
  1. Robert Weis
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  2. Marcel Kaiser
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  3. Reto Brun
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  4. Robert Saf
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  5. Werner Seebacher
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Corresponding author

Correspondence to Robert Weis.

Additional information

Correspondence: Robert Weis, Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Universitätsplatz 1, A-8010 Graz, Austria.

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Weis, R., Kaiser, M., Brun, R. et al. Acyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes. Monatsh Chem 139, 717–724 (2008). https://doi.org/10.1007/s00706-007-0815-y

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  • DOI: https://doi.org/10.1007/s00706-007-0815-y

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