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An efficient Mannich-type synthesis of bis(pyrido[2,1-b][1,3,5]thiadiazin-7-yl)-methanes

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Abstract

Morpholinium 3-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-thiolate upon treatment with primary amines and a formaldehyde excess under mild conditions produces bis(pyrido[2,1-b][1,3,5]thiadiazin-7-yl)methane derivatives in good yields (67–87%).

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Authors and Affiliations

  1. State Enterprise “Luganskstandartmetrology”, Lugansk, Ukraine

    Victor V. Dotsenko

  2. Vladimir Dal’ East Ukrainian National University, Lugansk, Ukraine

    Victor V. Dotsenko & Sergey G. Krivokolysko

  3. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    Victor P. Litvinov

Authors
  1. Victor V. Dotsenko
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  2. Sergey G. Krivokolysko
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  3. Victor P. Litvinov
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Correspondence to Victor V. Dotsenko.

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Correspondence: Victor V. Dotsenko, State Enterprise “Luganskstandartmetrology”, 91021 Lugansk, Ukraine.

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Dotsenko, V., Krivokolysko, S. & Litvinov, V. An efficient Mannich-type synthesis of bis(pyrido[2,1-b][1,3,5]thiadiazin-7-yl)-methanes. Monatsh Chem 139, 657–661 (2008). https://doi.org/10.1007/s00706-007-0809-9

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