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Antiprotozoal Activities of Epimeric Aminobicycles

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Summary.

We synthesized several 4-aminobicyclo[2.2.2] octan-2-ols and 4-amino-2-azabicyclo[3.2.2]nonanes from epimerized 4-amino-bicyclo[2.2.2]octan-2-ones. The new compounds were tested for their activity against Trypanosoma b. rhodesiense, the causative organism of East African sleeping sickness, and Plasmodium falciparum K 1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly synthesized stereoisomers and structure–activity relationships are discussed.

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Graz, Austria

    Werner Seebacher & Robert Weis

  2. Swiss Tropical Institute, Basel, Switzerland

    Marcel Kaiser & Reto Brun

  3. Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, Graz, Austria

    Robert Saf

Authors
  1. Werner Seebacher
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  2. Marcel Kaiser
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  3. Reto Brun
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  4. Robert Saf
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  5. Robert Weis
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Correspondence to Werner Seebacher.

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Seebacher, W., Kaiser, M., Brun, R. et al. Antiprotozoal Activities of Epimeric Aminobicycles. Monatsh. Chem. 138, 709–714 (2007). https://doi.org/10.1007/s00706-007-0670-x

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  • DOI: https://doi.org/10.1007/s00706-007-0670-x

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