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The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes

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Abstract

3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side chains, being part of drugs in use, to the ring nitrogen. The structures of the new compounds were established using one and two dimensional NMR measurements. All compounds were investigated for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K 1 (multiresistant) and Trypanosoma brucei rhodesiense. Their cytotoxicity was assessed against L6 cells. The results are compared to the activities of formerly synthesized compounds. Structure–activity relationships are discussed.

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Authors and Affiliations

  1. Center for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan

    Sarfraz Ahmad

  2. Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010, Graz, Austria

    Werner Seebacher, Johanna Faist & Robert Weis

  3. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland

    Marcel Kaiser & Reto Brun

  4. Institute for Chemistry and Technology of Materials (ICTM), Graz University of Technology, Stremayrgasse 9, 8010, Graz, Austria

    Robert Saf

  5. University of Basel, Petersplatz 1, 4003, Basel, Switzerland

    Marcel Kaiser & Reto Brun

Authors
  1. Sarfraz Ahmad
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  2. Werner Seebacher
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  3. Johanna Faist
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  4. Marcel Kaiser
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  5. Reto Brun
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  6. Robert Saf
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  7. Robert Weis
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Corresponding author

Correspondence to Werner Seebacher.

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Ahmad, S., Seebacher, W., Faist, J. et al. The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Arch. Pharm. Res. 39, 1391–1403 (2016). https://doi.org/10.1007/s12272-016-0826-5

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  • DOI: https://doi.org/10.1007/s12272-016-0826-5

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