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Synthesis of Anticancer Compounds, I, “Dual Function” Antitumor Agents Based on Bioreduction and DNA-Alkylation

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Summary.

We report the synthesis of novel anticancer compounds based on bioreductive and DNA-alkylating properties. The strategy was to combine a benzoquinone annelated pyrrole with bioreductive properties with a set of DNA-alkylating functionalities, thus resulting in bifunctional anticancer compounds. The biological activity of all compounds was evaluated against a number of cancer cell lines. One of the compounds should be emphasized.

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Authors and Affiliations

  1. Department of Drug Synthesis, University of Vienna, Vienna

    Helmut Spreitzer & Christiane Puschmann

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  1. Helmut Spreitzer
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  2. Christiane Puschmann
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Correspondence to Helmut Spreitzer.

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Spreitzer, H., Puschmann, C. Synthesis of Anticancer Compounds, I, “Dual Function” Antitumor Agents Based on Bioreduction and DNA-Alkylation. Monatsh. Chem. 138, 517–522 (2007). https://doi.org/10.1007/s00706-007-0604-7

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  • DOI: https://doi.org/10.1007/s00706-007-0604-7

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