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Antimicrobial Activity and Structural Study of Disubstituted Thiourea Derivatives

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Summary.

The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included.

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Authors and Affiliations

  1. Instituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador, BA, Brazil

    Silvio Cunha, Fernando C. Macedo Jr, Giselle A. N. Costa, Manoel T. Rodrigues Jr, Rosival B. V. Verde & Lourdes C. de Souza Neta

  2. Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis, GO, Brazil

    Ivo Vencato

  3. Instituto de Física, Universidade Federal de Goiás, Goiânia, GO, Brazil

    Ivo Vencato, Carlito Lariucci & Fernando P. Sá

Authors
  1. Silvio Cunha
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  2. Fernando C. Macedo Jr
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  3. Giselle A. N. Costa
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  4. Manoel T. Rodrigues Jr
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  5. Rosival B. V. Verde
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  6. Lourdes C. de Souza Neta
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  7. Ivo Vencato
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  8. Carlito Lariucci
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  9. Fernando P. Sá
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Correspondence to Silvio Cunha.

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Cunha, S., Macedo, F., Costa, G. et al. Antimicrobial Activity and Structural Study of Disubstituted Thiourea Derivatives. Monatsh. Chem. 138, 511–516 (2007). https://doi.org/10.1007/s00706-007-0600-y

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  • DOI: https://doi.org/10.1007/s00706-007-0600-y

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