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On the Synthesis of Pyrrolobenzo[b]thieno[1,4]diazepines

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Summary.

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was converted into the corresponding 2-(pyrrol-1-yl) derivative, followed by reduction of the latter compound into the corresponding amine. This amine and its acyl, aroyl, and arylidene derivatives were used as synthons in the synthesis of several title compounds.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

    Hussein El-Kashef

  2. Laboratoire de Chimie Organique Pharmaceutique (LCOP) UMR CNRS 6517, Faculté de Pharmacie, Université de la Méditerranée, Marseille, France

    Pascal Rathelot & Patrice Vanelle

  3. UPRES-EA 2126: Centre d’Etudes et de Recherche sur le Médicament de Normandie, U.F.R. des Sciences pharmaceutiques, Université de Caen Basse-Normandie, Caen, France

    Sylvain Rault

Authors
  1. Hussein El-Kashef
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  2. Pascal Rathelot
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  3. Patrice Vanelle
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  4. Sylvain Rault
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Corresponding author

Correspondence to Hussein El-Kashef.

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El-Kashef, H., Rathelot, P., Vanelle, P. et al. On the Synthesis of Pyrrolobenzo[b]thieno[1,4]diazepines. Monatsh. Chem. 138, 469–476 (2007). https://doi.org/10.1007/s00706-007-0591-8

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  • DOI: https://doi.org/10.1007/s00706-007-0591-8

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