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An Efficient and Practical Method for the Synthesis of 1-(2,6-Difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as Potential Chitin Synthesis Inhibitors

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Summary.

A mild and efficient method for the synthesis of 4-amino-3(2H)-pyridazinones from their corresponding 4,5-dichloropyridazinones under microwave-assisted conditions is described. A series of novel chitin synthesis inhibitors, benzoylphenylureas containing the 3(2H)-pyridazinone, were synthesized. The biological activity of these target compounds was evaluated.

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Authors and Affiliations

  1. Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai, China

    Song Cao, De-Li Lu, Chuan-Meng Zhao, Li-Na Li, Qing-Chun Huang & Xu-Hong Qian

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  1. Song Cao
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  2. De-Li Lu
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  3. Chuan-Meng Zhao
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  4. Li-Na Li
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  5. Qing-Chun Huang
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  6. Xu-Hong Qian
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Corresponding authors

Correspondence to Song Cao or Xu-Hong Qian.

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Cao, S., Lu, DL., Zhao, CM. et al. An Efficient and Practical Method for the Synthesis of 1-(2,6-Difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as Potential Chitin Synthesis Inhibitors. Monatsh. Chem. 137, 779–784 (2006). https://doi.org/10.1007/s00706-005-0476-7

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  • DOI: https://doi.org/10.1007/s00706-005-0476-7

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