Summary.
4-Aminobicyclo[2.2.2]octanones which were prepared in one-pot-reactions from benzylidene acetone and dialkylammonium rhodanides were reduced stereoselectively to their corresponding alcohols. The activities of the bicyclic compounds against causative organisms of tropical deseases were examined. The 4-aminobicyclo[2.2.2]octan-2-ols were in general more active against Trypanosoma b. rhodesiense and Plasmodium falciparum than the corresponding keto compounds.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Corresponding author. E-mail: robert.weis@uni-graz.at
Received November 27, 2002; accepted December 2, 2002 Published online May 2, 2003
Rights and permissions
About this article
Cite this article
Weis, R., Brun, R., Saf, R. et al. 4-Aminobicyclo[2.2.2]octanone Derivatives with Antiprotozoal Activities. Monatshefte für Chemie 134, 1019–1026 (2003). https://doi.org/10.1007/s00706-003-0011-7
Issue Date:
DOI: https://doi.org/10.1007/s00706-003-0011-7