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The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

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Summary

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation.

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Authors and Affiliations

  1. Department of Infection, The Medical School, University of Birmingham, Birmingham, U.K., UK

    C. E. Bolt & G. R. B. Skinner

  2. Vaccine Research Trust, Birmingham, U.K., UK

    J. A. Davies

  3. Department of Virology, St. Bartholomew’s Hospital, London, U.K., UK

    S. Randall

Authors
  1. C. E. Bolt
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  2. J. A. Davies
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  3. S. Randall
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  4. G. R. B. Skinner
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Accepted November 18, 1997 Received June 30, 1997

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Bolt, C.E., Davies, J.A., Randall, S. et al. The influence of the milieu on the rate of neutralisation of herpes simplex virus 1. Arch. Virol. 143, 549–556 (1998). https://doi.org/10.1007/s007050050310

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  • DOI: https://doi.org/10.1007/s007050050310

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