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Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study

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Abstract

Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases in swine, the most common of which are postweaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). To investigate the prevalence and genetic diversity of PCV2 in Hebei Province, Northern China, from 2016 to 2019, a total of 448 suspected cases of PCV2 infection were studied, and 179 samples were positive for PCV2. A pathological and histopathological examination suggested PCV2 to be cause of the observed lesions. Phylogenetic analysis showed that four genotypes were prevalent in Hebei Province: PCV2a, 2b, 2d, and 2e. Analysis of PCV2 strains using RDP4 and SimPlot showed that there were genetic recombination events among PCV2 strains in Hebei Province. A total of 3284 serum samples were screened by ELISA, and the positive rate of PCV2 antibodies was 73.9% (2428/3284). This study provides a scientific reference for the prevention and treatment of PCV2 in Hebei Province.

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Funding

This research was supported by the Program of the Modern Agriculture Industry Technology System Foundation of Hebei Province (HBCT2018110207), Science and Technology Innovation Program of Hebei Province for Graduate Students (CXZZBS2019095), and Key R & D Projects in Hebei Province, China (19226622D).

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Author notes

  1. Lei Han, Guang-fu Yuan and Shao-jie Chen contributed equally to this work.

Authors and Affiliations

  1. College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, People’s Republic of China

    Lei Han, Guang-fu Yuan, Shao-jie Chen, Fei Dai, Lin-shan Hou, Jing-hui Fan & Yu-zhu Zuo

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  1. Lei Han
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  2. Guang-fu Yuan
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  3. Shao-jie Chen
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  6. Jing-hui Fan
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  7. Yu-zhu Zuo
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Contributions

YZZ and JHF as corresponding authors contributed to the conception of the study. LH, GFY, and SJC performed the data analysis and wrote the manuscript. FD and LSH contributed significantly to analysis and manuscript preparation. All authors have read and approved the manuscript.

Corresponding authors

Correspondence to Jing-hui Fan or Yu-zhu Zuo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

Animal experiments were approved by the Animal Ethics Committee of Hebei Agricultural University (2019022). Permission was obtained from the farm owners for collection of samples.

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All data and material generated or used during the study appear in the submitted article.

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Handling Editor: Ana Cristina Bratanich.

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Han, L., Yuan, Gf., Chen, Sj. et al. Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study. Arch Virol 166, 2159–2171 (2021). https://doi.org/10.1007/s00705-021-05085-z

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  • DOI: https://doi.org/10.1007/s00705-021-05085-z

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