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Isolation and characterization of an avian-origin H3N8 canine influenza virus from a dog in eastern China

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Abstract

Previous studies have shown that dogs are susceptible to influenza A viruses, and the close contact between dogs and humans poses a threat to public health. In 2015, a novel H3N8 influenza virus was isolated from a dog in eastern China. This strain was characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison and found to be most closely related to avian influenza viruses co-circulating in China. It was able to replicate in mice without prior adaptation. The continued circulation of this novel H3N8 influenza virus in dogs could endanger other mammalian species.

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Funding

This study was funded by the 2017 Dezhou University Talent Project (320202) and National Science Foundation of the People’s Republic of China (81502852).

Author information

Authors and Affiliations

  1. Dezhou College, Dezhou, 253023, Shandong, China

    Xueliang Cao & Shiying Zheng

  2. Shandong Vocational Animal Science and Veterinary College, Weifang, 261061, Shandong, China

    Xinbo Liu

  3. Animal Husbandry and Veterinary Institute, Zhejiang Academy of Agricultural Science, Hangzhou, 310021, Zhejiang, China

    Lihua Xu

  4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China

    Haibo Wu

  5. Animal Hospital of Zhejiang University, Hangzhou, 310058, Zhejiang, China

    Jie Liu

Authors
  1. Xueliang Cao
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  2. Xinbo Liu
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  3. Shiying Zheng
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  4. Lihua Xu
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  5. Haibo Wu
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  6. Jie Liu
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Corresponding author

Correspondence to Xueliang Cao.

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Conflict of interest

The authors declare that they had no conflict of interest.

Ethical approval

The animal studies were approved by Zhejiang University (No. ZJU2015-045-01).

Additional information

Handling Editor: Ayato Takada.

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Cao, X., Liu, X., Zheng, S. et al. Isolation and characterization of an avian-origin H3N8 canine influenza virus from a dog in eastern China. Arch Virol 163, 1955–1960 (2018). https://doi.org/10.1007/s00705-018-3818-6

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  • DOI: https://doi.org/10.1007/s00705-018-3818-6

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