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Genomic and phylogenetic characterization of Shuni virus

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Abstract

Shuni virus (SHUV), a member of the genus Orthobunyavirus, has in a recent study been associated with neurological disease in horses in South Africa. After its first isolation in 1966 from an asymptomatic bovine, very little attention was given to the genetic characterisation of SHUV. The association of SHUV with severe neurological disease in several horses in South Africa prompted us to determine the full genome sequence of a horse neurovirulent isolate to compare it to other members of the genus Orthobunyavirus, as well as the partially sequenced genome of the prototype SHUV strain. The availability of a full genome sequence will facilitate the development of a reverse genetics system to study SHUV molecular biology and pathogenesis.

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Acknowledgments

This study was funded by the Global Disease Detection (GDD) programme of the Centres for Disease Control and Prevention (CDC), Atlanta, USA.

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Author notes

  1. Marietjie Venter

    Present address: Division of Global Health Protection, US Centres for Disease Control and Prevention, Pretoria, South Africa

Authors and Affiliations

  1. Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Pretoria, South Africa

    Charmaine van Eeden & Marietjie Venter

  2. Central Veterinary Institute, Part of Wageningen University and Research Centre, Wageningen, The Netherlands

    Frank Harders, Jeroen Kortekaas & Alex Bossers

Authors
  1. Charmaine van Eeden
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  2. Frank Harders
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  3. Jeroen Kortekaas
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  4. Alex Bossers
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  5. Marietjie Venter
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Corresponding author

Correspondence to Marietjie Venter.

Additional information

Accession numbers: The GenBank accession numbers for SAE 18/09 are KC510272 for the S segment, KF153117 for the M segment and KF153118 for the L segment.

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van Eeden, C., Harders, F., Kortekaas, J. et al. Genomic and phylogenetic characterization of Shuni virus. Arch Virol 159, 2883–2892 (2014). https://doi.org/10.1007/s00705-014-2131-2

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  • DOI: https://doi.org/10.1007/s00705-014-2131-2

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