Abstract
CK10 and GS10 are two H5N1 highly pathogenic influenza viruses of similar genetic background but differ in their pathogenicity in mallard ducks. CK10 is highly pathogenic whereas GS10 is low pathogenic. In this study, strong inflammatory response in terms of the expression level of several cytokines was observed in mallard duck peripheral blood mononuclear cells (PBMC) infected with CK10 while mild response was triggered in those by GS10 infection. Two remarkable and intense peaks of immune response were induced by CK10 infection within 24 hours (at 8 and 24 hours post infection, respectively) without reducing the virus replication. Our observations indicated that sustained and intense innate immune responses may be central to the high pathogenicity caused by CK10 in ducks.
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Acknowledgements
This work was supported by the Chinese National High-tech R&D Program (863 Program, grant number 2011AA10A200), by the earmarked fund for Modern Agro-industry Technology Research System (nycytx-41-G07) and by A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
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Cui, Z., Hu, J., He, L. et al. Differential immune response of mallard duck peripheral blood mononuclear cells to two highly pathogenic avian influenza H5N1 viruses with distinct pathogenicity in mallard ducks. Arch Virol 159, 339–343 (2014). https://doi.org/10.1007/s00705-013-1820-6
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DOI: https://doi.org/10.1007/s00705-013-1820-6