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Cell type-specific regulation of IL-10 expression in inflammation and disease

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Abstract

IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate temporal/spatial expression of IL-10 may be the key to how IL-10 contributes to the delicate balance between inflammation and immunoregulation. The mechanisms that govern the cell type- and receptor-specific induction of IL-10, however, remain unclear. This is due largely to the wide distribution of cellular sources that express IL-10 under diverse stimulation conditions and in a variety of tissue compartments. Further complicating the issue is the fact that human IL-10 expression patterns appear to be under genetic influence resulting in differential expression and disease susceptibility. In this review, we discuss the cellular sources of IL-10, their link to disease phenotypes and the molecular mechanisms implicated in IL-10 regulation.

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  1. Christian M. Hedrich

    Present address: Department of Pediatric Rheumatology and Immunology, Children’s Hospital Dresden, University Medical Center, “Carl Gustav Carus”, Dresden, Germany

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  1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Room E5624, Baltimore, MD, 21205-1901, USA

    Christian M. Hedrich & Jay H. Bream

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Hedrich, C.M., Bream, J.H. Cell type-specific regulation of IL-10 expression in inflammation and disease. Immunol Res 47, 185–206 (2010). https://doi.org/10.1007/s12026-009-8150-5

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