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The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared to oral health providers and healthy controls

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Abstract

The causative agents in periodontal disease are periopathogenic bacteria; however, viruses have been implicated. The aim of this study was to examine the prevalence of different HHVs in the saliva of chronic periodontitis patients and to compare it to two groups of healthy controls. Three groups were included: chronic periodontitis patients (CP), periodontally healthy patients (NP) and oral health providers with a healthy periodontium (NPOHP). For each subject, 1 ml of unstimulated whole saliva was collected and mixed with 2 ml lysis buffer. HHVs assays were performed using real-time PCR. Fifteen percent of the subjects in the CP group tested positive for CMV compared to none in the NP and NPOHP groups (p = 0.04). Recurrent herpes was more frequent in females (51.7 %) than in males (33.3 %), and this was statistically significant (p = 0.038). The higher prevalence of CMV in the unstimulated saliva of CP patients suggests that CMV may play a role in the pathogenesis of chronic periodontitis.

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Conflict of interest

The authors report no conflicts of interest related to this study, which was wholly supported by the authors.

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Authors and Affiliations

  1. Department of Periodontology and Oral Medicine, School of Graduate Dentistry, Rambam Health Care Campus, P.O.Box 9602, 31096, Haifa, Israel

    Leon Bilder, Rina Elimelech & Eli E. Machtei

  2. Laboratory of Clinical Virology, Rambam Health Care Campus, Haifa, Israel

    Moran Szwarcwort-Cohen & Zipi Kra-Oz

Authors
  1. Leon Bilder
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  2. Rina Elimelech
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  3. Moran Szwarcwort-Cohen
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  4. Zipi Kra-Oz
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  5. Eli E. Machtei
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Correspondence to Leon Bilder.

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Bilder, L., Elimelech, R., Szwarcwort-Cohen, M. et al. The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared to oral health providers and healthy controls. Arch Virol 158, 1221–1226 (2013). https://doi.org/10.1007/s00705-013-1609-7

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  • DOI: https://doi.org/10.1007/s00705-013-1609-7

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