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Antiviral aptamers

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Summary

Aptamers are rare nucleic acid ligands, which can be concocted in the laboratory from the randomized pool of molecules by affinity and amplification processes. Aptamers have several properties as they can be applied complementarily to antibodies and have several advantages over antibodies. In the past, several aptamers have been selected with a view to develop antiviral agents for therapeutic applications. This review summarizes potent antiviral aptamers and their strategies to prevent the viral replication.

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References

  • H Akiyama S Kachi RL Silva N Umeda SF Hackett D McCauley T McCauley A Zoltoski DM Epstein PA Campochiaro (2006) ArticleTitleIntraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies J Cell Physiol 207 407–412 Occurrence Handle16419035 Occurrence Handle10.1002/jcp.20583 Occurrence Handle1:CAS:528:DC%2BD28Xjs1yltLo%3D

    Article  PubMed  CAS  Google Scholar 

  • L Aldaz-Carroll B Tallet E Dausse L Yurchenko JJ Toulme (2002) ArticleTitleApical loop-internal loop interactions: a new RNA–RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA Biochemistry 41 5883–5893 Occurrence Handle11980492 Occurrence Handle10.1021/bi0121508 Occurrence Handle1:CAS:528:DC%2BD38XjtF2jsLc%3D

    Article  PubMed  CAS  Google Scholar 

  • P Allen B Collins D Brown Z Hostomsky L Gold (1996) ArticleTitleA specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7) Virology 226 306–315 Occurrence Handle10.1006/viro.1996.0605

    Article  Google Scholar 

  • P Allen S Worland L Gold (1995) ArticleTitleIsolation of high-affinity RNA ligand to HIV-integrase from a random pool Virology 209 327–336 Occurrence Handle7778267 Occurrence Handle10.1006/viro.1995.1264 Occurrence Handle1:CAS:528:DyaK2MXmt1ymsbk%3D

    Article  PubMed  CAS  Google Scholar 

  • ML Andreola F Pileur C Calmels M Ventura L Tarrago-Litvak JJ Toulme S Litvak (2001) ArticleTitleDNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity Biochemistry 40 10087–10094 Occurrence Handle11513587 Occurrence Handle10.1021/bi0108599 Occurrence Handle1:CAS:528:DC%2BD3MXlsFygtrk%3D

    Article  PubMed  CAS  Google Scholar 

  • S Baskerville M Zapp AD Ellington (1995) ArticleTitleHigh-resolution mapping of the human T-cell leukemia virus type-1 Rex-binding element by in vitro selection J Virol 69 7559–7569 Occurrence Handle7494262 Occurrence Handle1:CAS:528:DyaK2MXptlOkt7c%3D

    PubMed  CAS  Google Scholar 

  • S Baskerville M Zapp AD Ellington (1999) ArticleTitleAnti-Rex aptamers as mimics of the Rex-binding element J Virol 73 4962–4971 Occurrence Handle10233958 Occurrence Handle1:CAS:528:DyaK1MXjtFerurw%3D

    PubMed  CAS  Google Scholar 

  • F Beaurain CD Primo JJ Toulme M Laguerre (2003) ArticleTitleMolecular dynamics reveals the stabilizing role of loop closing residues in kissing interactions: comparison between TAR-TAR* and TAR-aptamer Nucleic Acids Res 31 4275–4284 Occurrence Handle12853646 Occurrence Handle10.1093/nar/gkg467 Occurrence Handle1:CAS:528:DC%2BD3sXltl2ksLY%3D

    Article  PubMed  CAS  Google Scholar 

  • P Bellecave ML Andreola M Ventura L Tarrago-Litvak S Litvak T Astier-Gin (2003) ArticleTitleSelection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro Oligonucleotides 13 455–463 Occurrence Handle15025912 Occurrence Handle10.1089/154545703322860771 Occurrence Handle1:CAS:528:DC%2BD2cXhs12ku78%3D

    Article  PubMed  CAS  Google Scholar 

  • JA Berglund B Charpentier M Rosbash (1997) ArticleTitleA high affinity site for the HIV-1 nucleocapsid protein Nucleic Acids Res 25 1042–1049 Occurrence Handle9023116 Occurrence Handle10.1093/nar/25.5.1042 Occurrence Handle1:CAS:528:DyaK2sXhvVagurc%3D

    Article  PubMed  CAS  Google Scholar 

  • A Biroccio J Hamm I Incitti RD Francesco L Tomei (2002) ArticleTitleSelection of RNA aptamers that are specific and high affinity ligands of the hepatitis C virus-dependent RNA polymerase J Virol 76 3688–3696 Occurrence Handle11907208 Occurrence Handle10.1128/JVI.76.8.3688-3696.2002 Occurrence Handle1:CAS:528:DC%2BD38XisVynu7k%3D

    Article  PubMed  CAS  Google Scholar 

  • C Boiziau E Dausse L Yurchenko JJ Toulme (1999) ArticleTitleDNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes J Biol Chem 274 12730–12737 Occurrence Handle10212256 Occurrence Handle10.1074/jbc.274.18.12730 Occurrence Handle1:CAS:528:DyaK1MXjtFGns7s%3D

    Article  PubMed  CAS  Google Scholar 

  • M Boyce F Scott LM Guogas L Gehrke (2006) ArticleTitleBase-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfaffa mosaic virus RNA-coat protein complex J Mol Recog 19 68–78 Occurrence Handle10.1002/jmr.759 Occurrence Handle1:CAS:528:DC%2BD28XosFCluw%3D%3D

    Article  CAS  Google Scholar 

  • D Brown L Gold (1995) ArticleTitleSelection and characterization of RNAs replicated by Qβ replicase Biochemistry 34 14775–14782 Occurrence Handle7578086 Occurrence Handle10.1021/bi00045a019 Occurrence Handle1:CAS:528:DyaK2MXovFSrt7k%3D

    Article  PubMed  CAS  Google Scholar 

  • KF Bryant JC Cox H Wang JM Hogle AD Ellington DM Coen (2005) ArticleTitleBinding of herpes simplex virus-1 US11 to specific RNA sequences Nucleic Acids Res 33 6090–6100 Occurrence Handle16246910 Occurrence Handle10.1093/nar/gki919 Occurrence Handle1:CAS:528:DC%2BD2MXht1entLjP

    Article  PubMed  CAS  Google Scholar 

  • L Chaloin MJ Lehmann G Scakiel T Restle (2002) ArticleTitleEndogenous expression of a high-affinity pseudoknow RNA aptamer suppresses replication of HIV-1 Nucleic Acids Res 30 4001–4008 Occurrence Handle12235384 Occurrence Handle10.1093/nar/gkf522 Occurrence Handle1:CAS:528:DC%2BD38Xnt1Gmsr4%3D

    Article  PubMed  CAS  Google Scholar 

  • H Chen L Gold (1994) ArticleTitleSelection of high-affinity RNA ligands to reverse transcriptase: inhibition of cDNA synthesis and RNase H activity Biochemistry 33 8746–8756 Occurrence Handle7518691 Occurrence Handle10.1021/bi00195a016 Occurrence Handle1:CAS:528:DyaK2cXlsleltrs%3D

    Article  PubMed  CAS  Google Scholar 

  • H Chen DG McBroom Y-Q Zhu L Gold TW North (1996) ArticleTitleInhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus Biochemistry 35 6923–6930 Occurrence Handle8639644 Occurrence Handle10.1021/bi9600106 Occurrence Handle1:CAS:528:DyaK28XivVSltbg%3D

    Article  PubMed  CAS  Google Scholar 

  • QL Choo G Kuo AJ Weiner LR Overby DW Bradley M Houghton (1989) ArticleTitleIsolation of cDNA clone derived from a bloodborne non-A, non-B viral hepatitis genome Science 244 359–362 Occurrence Handle2523562 Occurrence Handle10.1126/science.2523562 Occurrence Handle1:CAS:528:DyaL1MXit1Khtrk%3D

    Article  PubMed  CAS  Google Scholar 

  • S Chou K Chin AH-J Wang (2005) ArticleTitleDNA aptamers as potential anti-HIV agents TRENDS Biochem Sci 30 231–234 Occurrence Handle15896739 Occurrence Handle10.1016/j.tibs.2005.03.004 Occurrence Handle1:CAS:528:DC%2BD2MXktFGjs7g%3D

    Article  PubMed  CAS  Google Scholar 

  • JL Clever RA Taplitz MA Lochrie B Polisky TG Parslow (2000) ArticleTitleA heterologous high-affinity RNA ligand for human immunodeficiency virus gag protein has RNA packaging activity J Virol 74 541–546 Occurrence Handle10590146 Occurrence Handle1:CAS:528:DC%2BD3cXkvVyl Occurrence Handle10.1128/JVI.74.1.541-546.2000

    Article  PubMed  CAS  Google Scholar 

  • C Collin V Heijenoort C Boiziau JJ Toulmé E Guittet (2000) ArticleTitleNMR characterization of a kissing complex formed between the TAR RNA element of HIV-1 and a DNA aptamer Nucleic Acids Res 28 3386–3391 Occurrence Handle10954609 Occurrence Handle10.1093/nar/28.17.3386 Occurrence Handle1:CAS:528:DC%2BD3cXmvVSntbY%3D

    Article  PubMed  CAS  Google Scholar 

  • AI Dayton JG Sodoski CA Rosen WC Goh WA Haseltine (1986) ArticleTitleThe trans-activator gene of the human T cell lymphotropic virus type III is required for replication Cell 44 941–947 Occurrence Handle2420471 Occurrence Handle10.1016/0092-8674(86)90017-6 Occurrence Handle1:CAS:528:DyaL28XhvVSruro%3D

    Article  PubMed  CAS  Google Scholar 

  • AK Dey M Khati M Tang R Wyatt SM Lea W James (2005) ArticleTitleAn aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction J Virol 79 13806–13810 Occurrence Handle16227301 Occurrence Handle10.1128/JVI.79.21.13806-13810.2005 Occurrence Handle1:CAS:528:DC%2BD2MXhtFKjtr3I

    Article  PubMed  CAS  Google Scholar 

  • M Dobbelstein T Shenk (1995) ArticleTitle In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries J Virol 69 8027–8034 Occurrence Handle7494316 Occurrence Handle1:CAS:528:DyaK2MXptlOrs70%3D

    PubMed  CAS  Google Scholar 

  • F Ducongé JJ Toulmé (1999) ArticleTitle In vitro selection identifies key determinants for loop–loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1 RNA 5 1605–1614 Occurrence Handle10606271 Occurrence Handle10.1017/S1355838299991318

    Article  PubMed  Google Scholar 

  • AG Fisher MB Feinberg SF Josephs ME Harper LM Marselle G Reyes MA Gonda A Aldovini C Debouk RC Gallow R Wong-Staal (1986) ArticleTitleThe trans-activator gene of HTLV-III is essential for virus replication Nature 320 367–371 Occurrence Handle3007995 Occurrence Handle10.1038/320367a0 Occurrence Handle1:CAS:528:DyaL28XitVWgsLw%3D

    Article  PubMed  CAS  Google Scholar 

  • AD Frankel JAT Young (1998) ArticleTitleHIV-1: fifteen proteins and an RNA Annu Rev Biochem 67 1–25 Occurrence Handle9759480 Occurrence Handle10.1146/annurev.biochem.67.1.1 Occurrence Handle1:CAS:528:DyaK1cXlsFOms7s%3D

    Article  PubMed  CAS  Google Scholar 

  • H Fu JW Guthrie CX Le (2005) ArticleTitleStudy of binding stoichiometries of the human immunodeficiency virus type 1 reverse transcriptase by capillary electrophoresis and laser-induced fluorescence polarization using aptamers as probes Electrophoresis 27 433–441 Occurrence Handle10.1002/elps.200500460 Occurrence Handle1:CAS:528:DC%2BD28XhsFeqt7c%3D

    Article  CAS  Google Scholar 

  • K Fukuda T Umehara S Sekiya K Kunio T Hasegawa S Nishikawa (2004) ArticleTitleAn RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities Biochem Biophy Res Commun 325 670–675 Occurrence Handle10.1016/j.bbrc.2004.10.089 Occurrence Handle1:CAS:528:DC%2BD2cXpslKgtL4%3D

    Article  CAS  Google Scholar 

  • K Fukuda D Vishnuvardhan S Sekiya J Hwang N Kakiuchi K Taira K Shimotohno PKR Kumar S Nishikawa (2000) ArticleTitleIsolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease Eur J Biochem 267 3685–3694 Occurrence Handle10848986 Occurrence Handle10.1046/j.1432-1327.2000.01400.x Occurrence Handle1:CAS:528:DC%2BD3cXksVKgtLk%3D

    Article  PubMed  CAS  Google Scholar 

  • M Garret P Romby R Giege S Litvak (1984) ArticleTitleInteractions between avian myeloblastosis reverse transcriptase and tRNATrp. Mapping of complexed tRNA with chemicals and nucleases Nucleic Acids Res 12 2259–2271 Occurrence Handle6200830 Occurrence Handle10.1093/nar/12.5.2259 Occurrence Handle1:CAS:528:DyaL2cXhvVKmt7s%3D

    Article  PubMed  CAS  Google Scholar 

  • R Gaynor (1992) ArticleTitleCellular transcription factors involved in the regulation of HIV-1 gene expression AIDS 6 347–363 Occurrence Handle1616633 Occurrence Handle10.1097/00002030-199204000-00001 Occurrence Handle1:CAS:528:DyaK3sXks12kurk%3D

    Article  PubMed  CAS  Google Scholar 

  • L Giver D Bartel M Zapp A Pawul M Green AD Ellington (1993) ArticleTitleSelective optimization of the Rev-binding element of HIV-1 Nucleic Acids Res 21 5509–5516 Occurrence Handle7505429 Occurrence Handle10.1093/nar/21.23.5509 Occurrence Handle1:CAS:528:DyaK2cXpvVSrsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • PD Good AJ Krikos SXL Li E Bertrand NS Lee L Giver AD Ellington JA Zaia JJ Rossi DR Engelke (1997) ArticleTitleExpression of small, therapeutic RNAs in human cell nuclei Gene Ther 4 45–54 Occurrence Handle9068795 Occurrence Handle10.1038/sj.gt.3300354 Occurrence Handle1:CAS:528:DyaK2sXot1WgsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SCB Gopinath (2007) ArticleTitleMethods developed for SELEX Anal Bioanal Chem 387 171–182 Occurrence Handle17072603 Occurrence Handle10.1007/s00216-006-0826-2 Occurrence Handle1:CAS:528:DC%2BD28Xhtlans7rI

    Article  PubMed  CAS  Google Scholar 

  • SCB Gopinath A Matsugami K Katahira PKR Kumar (2005) ArticleTitleHuman vault-associated non-coding RNAs bind to mitoxantrone, a chemotherapeutic compound Nucleic Acids Res 33 4874–4881 Occurrence Handle16150923 Occurrence Handle1:CAS:528:DC%2BD2MXpvFKjtb8%3D

    PubMed  CAS  Google Scholar 

  • SCB Gopinath T Misono T Mizuno K Kawasaki PKR Kumar (2006) ArticleTitleAn RNA aptamer that distinguishes between closely related human influenza viruses and inhibits hemagglutinin-mediated membrane fusion J Gen Virol 87 479–487 Occurrence Handle16476969 Occurrence Handle10.1099/vir.0.81508-0 Occurrence Handle1:CAS:528:DC%2BD28XitVahsLY%3D

    Article  PubMed  CAS  Google Scholar 

  • SCB Gopinath Y Sakamaki K Kawasaki PKR Kumar (2006) ArticleTitleAn efficient RNA aptamer against human influenza B virus hemagglutinin J Biochem 139 837–846 Occurrence Handle16751591 Occurrence Handle10.1093/jb/mvj095 Occurrence Handle1:CAS:528:DC%2BD28XmtlKqtrg%3D

    Article  PubMed  CAS  Google Scholar 

  • LM Guogas DJ Filman JM Hogle L Gehrke (2004) ArticleTitleCofolding organizes alfalfa mosaic virus RNA and coat protein for replication Science 306 2108–2111 Occurrence Handle15604410 Occurrence Handle10.1126/science.1103399 Occurrence Handle1:CAS:528:DC%2BD2cXhtVOjsLrI

    Article  PubMed  CAS  Google Scholar 

  • MR Hilleman (2003) ArticleTitleCritical overview and outlook: pathogenesis, prevention, and treatment of hepatitis and hepatocarcinoma caused by hepatitis B virus Vaccine 21 4626–4649 Occurrence Handle14585670 Occurrence Handle10.1016/S0264-410X(03)00529-2 Occurrence Handle1:CAS:528:DC%2BD3sXosVKktbw%3D

    Article  PubMed  CAS  Google Scholar 

  • F Houser-Scott P Ansel-Mckinney J Cai L Gehrke (1997) ArticleTitle In vitro genetic selection analysis of Alfalfa Mosaic Virus coat protein binding to 3′-terminal AUGC repeats in the viral RNAs J Virol 71 2310–2319 Occurrence Handle9032367 Occurrence Handle1:CAS:528:DyaK2sXht1Wktr0%3D

    PubMed  CAS  Google Scholar 

  • B Hwang JS Cho HJ Yeo JH Kim KM Chung K Han SK Jang SW Lee (2004) ArticleTitleIsolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus RNA 10 1277–1290 Occurrence Handle15247433 Occurrence Handle10.1261/rna.7100904 Occurrence Handle1:CAS:528:DC%2BD2cXmtlKlsbg%3D

    Article  PubMed  CAS  Google Scholar 

  • A Jacobo-Molina E Arnold (1991) ArticleTitleHIV reverse transcriptase structure-function relationships Biochem 30 6351–6361 Occurrence Handle10.1021/bi00240a001 Occurrence Handle1:CAS:528:DyaK3MXkt1Crsr4%3D

    Article  CAS  Google Scholar 

  • KB Jensen BL Atkinson MC Willis TH Koch L Gold (1995) ArticleTitleUsing in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 rev protein to high-affinity RNA ligands Proc Natl Acad Sci USA 92 12220–12224 Occurrence Handle8618873 Occurrence Handle10.1073/pnas.92.26.12220 Occurrence Handle1:CAS:528:DyaK28Xhtl2gsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SH Jeon B Kayhan T Ben-Yadidia R Arnon (2004) ArticleTitleA DNA aptamer prevents influenza infection by blocking the receptor binding region of the viral Hemagglutinin J Biol Chem 279 48410–48419 Occurrence Handle15358767 Occurrence Handle10.1074/jbc.M409059200 Occurrence Handle1:CAS:528:DC%2BD2cXptl2msrg%3D

    Article  PubMed  CAS  Google Scholar 

  • N Jing C Marchand J Liu R Mitra ME Hogan Y Pommier (2000) ArticleTitleMechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonuclotides in vitro J Biol Chem 28 21460–21467 Occurrence Handle10.1074/jbc.M001436200

    Article  Google Scholar 

  • PJ Joshi TS Fisher VR Prasad (2003) ArticleTitleAnti-HIV inhibitors based on nucleic acids: emergence of aptamers as potent antiviral Curr Drug Targets-Infect Disord 3 255–262 Occurrence Handle10.2174/1568005033481097

    Article  Google Scholar 

  • P Joshi VR Prasad (2002) ArticleTitlePotent inhibition of human immunodeficiency virus type 1 replication by template analog reverse transcriptase inhibitors derived by SELEX (Systematic Evolution of ligands by Exponential enrichment) J Virol 76 6545–6557 Occurrence Handle12050367 Occurrence Handle10.1128/JVI.76.13.6545-6557.2002 Occurrence Handle1:CAS:528:DC%2BD38XkvVGhtrs%3D

    Article  PubMed  CAS  Google Scholar 

  • M Khati M Schuman J Ibrahim Q Sattentau S Gordon W James (2003) ArticleTitleNeutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 2′F-RNA aptamers J Virol 77 12692–12698 Occurrence Handle14610191 Occurrence Handle10.1128/JVI.77.23.12692-12698.2003 Occurrence Handle1:CAS:528:DC%2BD3sXptFOjs7s%3D

    Article  PubMed  CAS  Google Scholar 

  • MY Kim S Jeong (2004) ArticleTitleInhibition of the functions of the nucleocapsid protein of human immunodeficiency virus-1 by an RNA aptamer Biochem Biophys Res Commun 320 1181–1186 Occurrence Handle15249214 Occurrence Handle10.1016/j.bbrc.2004.06.077 Occurrence Handle1:CAS:528:DC%2BD2cXls1eis7s%3D

    Article  PubMed  CAS  Google Scholar 

  • SJ Kim MY Kim JH Lee JC You S Jeong (2002) ArticleTitleSelection and stabilization of the RNA aptamers against the human immunodeficiency virus type-1 nucleocapsid protein Biochem Biophys Res Commun 291 925–931 Occurrence Handle11866454 Occurrence Handle10.1006/bbrc.2002.6521 Occurrence Handle1:CAS:528:DC%2BD38XhsFWjs7o%3D

    Article  PubMed  CAS  Google Scholar 

  • K Kikuchi T Umehara K Fukuda A Kuno T Hasegawa S Nishikawa (2005) ArticleTitleA hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId Nucleic Acids Res 33 683–692 Occurrence Handle15681618 Occurrence Handle10.1093/nar/gki215 Occurrence Handle1:CAS:528:DC%2BD2MXhtV2qt70%3D

    Article  PubMed  CAS  Google Scholar 

  • D Kobasa A Takada K Shinya M Hatta P Halfmann S Theriault H Suzuki H Nishimura K Mitamura N Sugaya T Usui T Murata Y Maeda S Watanabe M Suresh T Suzuki Y Suzuki H Feldmann Y Kawaoka (2004) ArticleTitleEnhanced virulence of influenza A viruses with the hemagglutinin of the 1918 pandemic virus Nature 43 703–707 Occurrence Handle10.1038/nature02951 Occurrence Handle1:CAS:528:DC%2BD2cXotFGrtbY%3D

    Article  CAS  Google Scholar 

  • PKR Kumar K Machida PT Urvil N Kakiuchi D Vishnuvardhan K Shimotohno K Taira S Nishikawa (1997) ArticleTitleIsolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA Virology 237 270–282 Occurrence Handle9356339 Occurrence Handle10.1006/viro.1997.8773 Occurrence Handle1:CAS:528:DyaK2sXnt12qu7g%3D

    Article  PubMed  CAS  Google Scholar 

  • G Kuo QL Choo HJ Alter GL Gitnick AG Redeker RH Purcell T Miyamura JL Deninstag MJ Alter CE Stevens GE Tegtmeier F Bonino M Colombo WS Lee C Kuo K Berger JR Shuster LR Overby DW Bradley M Houghton (1989) ArticleTitleAn assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis Science 244 362–364 Occurrence Handle2496467 Occurrence Handle10.1126/science.2496467 Occurrence Handle1:CAS:528:DyaL1MXit12lu7w%3D

    Article  PubMed  CAS  Google Scholar 

  • AD Kwong JL Kim C Lin (2000) ArticleTitleStructure and function of hepatitis C virus NS3 helicase Curr Top Microb Immunol 242 171–196 Occurrence Handle1:CAS:528:DyaK1MXns1Krtb4%3D

    CAS  Google Scholar 

  • MA Lochrie S Waugh DG Pratt SuffixJr J Clever TG Parslow B Polisky (1997) ArticleTitle In vitro selection of RNAs that bind to the human immunodeficiency virus type-1 gag protein Nucleic Acid Res 25 2902–2910 Occurrence Handle9207041 Occurrence Handle10.1093/nar/25.14.2902 Occurrence Handle1:CAS:528:DyaK2sXks1KjsLs%3D

    Article  PubMed  CAS  Google Scholar 

  • A Mescalchin W Wunsche SD Laufer D Grohman T Restle G Sczakiel (2006) ArticleTitleSpecific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules Nucleic Acids Res 34 5631–5637 Occurrence Handle17038335 Occurrence Handle10.1093/nar/gkl533 Occurrence Handle1:CAS:528:DC%2BD28Xht1Srt7nF

    Article  PubMed  CAS  Google Scholar 

  • T Misono PKR Kumar (2005) ArticleTitleSelection of RNA aptamers against human influenza virus hemagglutinin using surface plasmon resonance Anal Biochemistry 342 312–317 Occurrence Handle10.1016/j.ab.2005.04.013 Occurrence Handle1:CAS:528:DC%2BD2MXlvVWrsLc%3D

    Article  CAS  Google Scholar 

  • EWM Ng DT Shima P Calias ET Cunningham SuffixJr DR Guyer PA Adamis (2006) ArticleTitlePegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease Nat Rev 5 123–132 Occurrence Handle1:CAS:528:DC%2BD28Xhslaqur8%3D

    CAS  Google Scholar 

  • JC Niles MA Marletta (2006) ArticleTitleUtilizing RNA aptamers to probe a physiologically important heme-regulated cellular network Chem Biol 8 515–524

    Google Scholar 

  • F Nishikawa K Funaji K Fukuda S Nishikawa (2004) ArticleTitle In vitro selection of RNA aptamers against the HCV NS3 helicase domain Oligonucleotides 14 114–129 Occurrence Handle15294075 Occurrence Handle10.1089/1545457041526335 Occurrence Handle1:CAS:528:DC%2BD2cXmtVOisbs%3D

    Article  PubMed  CAS  Google Scholar 

  • T Noda H Sagara A Yen A Takada H Kida H Cheng Y Kawaoka (2006) ArticleTitleArchitecture of ribonucleoprotein complexes in influenza A virus particles Nature 439 490–492 Occurrence Handle16437116 Occurrence Handle10.1038/nature04378 Occurrence Handle1:CAS:528:DC%2BD28XntFWlsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • W Pan RC Craven Q Qiu CB Wilson JW Wills S Golovine JF Wang (1995) ArticleTitleIsolation of virus-neutralizing RNAs from a large pool of random sequences Proc Natl Acad Sci USA 92 11509–11513 Occurrence Handle8524793 Occurrence Handle10.1073/pnas.92.25.11509 Occurrence Handle1:CAS:528:DyaK2MXpvVOgu7w%3D

    Article  PubMed  CAS  Google Scholar 

  • NC Pedersen EW Ho ML Brown JK Yamamoto (1987) ArticleTitleIsolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome Science 235 790–793 Occurrence Handle3643650 Occurrence Handle10.1126/science.3643650 Occurrence Handle1:STN:280:DyaL2s7itVehsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • F Pileur M Andreola E Dausse J Michel S Moreau H Yamada SA Gaidamakov RJ Crouch J Toulme C Cazenave (2003) ArticleTitleSelective inhibitory DNA aptamers of the human RNase H1 Nucleic Acids Res 31 5776–5788 Occurrence Handle14500841 Occurrence Handle10.1093/nar/gkg748 Occurrence Handle1:CAS:528:DC%2BD3sXns1Cnt7o%3D

    Article  PubMed  CAS  Google Scholar 

  • P Purohit S Dupont M Stevenson MR Green (2001) ArticleTitleSequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection RNA 7 576–584 Occurrence Handle11345436 Occurrence Handle10.1017/S1355838201002023 Occurrence Handle1:CAS:528:DC%2BD3MXjtVeitb0%3D

    Article  PubMed  CAS  Google Scholar 

  • A Rieger M Nassal (1995) ArticleTitleDistinct requirements for primary sequence in the 5′- and 3′-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system Nucleic Acids Res 23 3909–3915 Occurrence Handle7479035 Occurrence Handle10.1093/nar/23.19.3909 Occurrence Handle1:CAS:528:DyaK2MXptFWlsrc%3D

    Article  PubMed  CAS  Google Scholar 

  • C Romero-Lopez A Barroso-delJesus E Puerta-Fernandez A Berzal-Herranz (2005) ArticleTitleInterfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method Biol Chem 386 183–190 Occurrence Handle15843163 Occurrence Handle10.1515/BC.2005.023 Occurrence Handle1:CAS:528:DC%2BD2MXit1Wjtrc%3D

    Article  PubMed  CAS  Google Scholar 

  • CA Rosen JG Sodroski WA Haseltine (1985) ArticleTitleThe location of cis-acting regulatory sequences in human T cell lymphotropic virus type III Cell 41 813–823 Occurrence Handle2988790 Occurrence Handle10.1016/S0092-8674(85)80062-3 Occurrence Handle1:CAS:528:DyaL2MXltFOhsLw%3D

    Article  PubMed  CAS  Google Scholar 

  • D Sekkai E Dausse C Di Primo F Darfeuille C Boiziau JJ Toulme (2002) ArticleTitle In vitro selection of DNA aptamers against the HIV-1 TAR RNA hairpin Antisense Nucleic Acid Drug Dev 12 265–274 Occurrence Handle12238815 Occurrence Handle10.1089/108729002320351584 Occurrence Handle1:CAS:528:DC%2BD38Xnt1eksro%3D

    Article  PubMed  CAS  Google Scholar 

  • K Shimotohno (1993) ArticleTitleHepatocellular carcinoma in Japan and its linkage to infection with hepatitis C virus Semin Virol 4 305–312 Occurrence Handle10.1006/smvy.1993.1027

    Article  Google Scholar 

  • JJ Skehel DC Wiley (2000) ArticleTitleReceptor binding and membrane fusion in virus entry: the influenza hemagglutinin Annu Rev Biochem 69 531–569 Occurrence Handle10966468 Occurrence Handle10.1146/annurev.biochem.69.1.531 Occurrence Handle1:CAS:528:DC%2BD3cXnt1ajtbY%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Tian N Adya S Wagner CZ Giam MR Green AD Ellington (1995) ArticleTitleDissecting protein:protein interactions between transcription factors with an RNA aptamer RNA 1 317–326 Occurrence Handle7489503 Occurrence Handle1:CAS:528:DyaK2MXmtFelt70%3D

    PubMed  CAS  Google Scholar 

  • S Tombelli M Minunni M Mascini (2005) ArticleTitleAnalytical applications of aptamers Biosens Bioelectron 20 2424–2434 Occurrence Handle15854817 Occurrence Handle10.1016/j.bios.2004.11.006 Occurrence Handle1:CAS:528:DC%2BD2MXjs1Knt7s%3D

    Article  PubMed  CAS  Google Scholar 

  • C Tuerk S MacDougal L Gold (1992) ArticleTitleRNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase Proc Natl Acad Sci USA 89 6988–6992 Occurrence Handle1379730 Occurrence Handle10.1073/pnas.89.15.6988 Occurrence Handle1:CAS:528:DyaK38XlsVCksLg%3D

    Article  PubMed  CAS  Google Scholar 

  • H Ulrich (2006) RNA aptamers: from basic science towards therapy K Starke (Eds) Handbook of experimental pharmacology NumberInSeries173 Springer Berlin Heidelberg New York Tokyo 305–326

    Google Scholar 

  • T Umehara K Fukuda F Nishikawa M Kohara T Hasegawa S Nishikawa (2005) ArticleTitleRational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3 J Biochem (Tokyo) 137 339–347 Occurrence Handle1:CAS:528:DC%2BD2MXlt1Cms7c%3D

    CAS  Google Scholar 

  • PT Urvil N Kakiuchi DM Zhou K Shimotohno PKR Kumar S Nishikawa (1997) ArticleTitleSelection of RNA aptamers that bind specifically to the NS3 protease of hepatitis C virus Eur J Biochem 248 130–138 Occurrence Handle9310370 Occurrence Handle10.1111/j.1432-1033.1997.t01-1-00130.x Occurrence Handle1:CAS:528:DyaK2sXmtFemtbw%3D

    Article  PubMed  CAS  Google Scholar 

  • NM Vo J Oh MMC Lai (2003) ArticleTitleIdentification of RNA ligands that bind hepatitis C virus polymerase selectively and inhibit its RNA synthesis from the natural viral RNA templates Virology 307 301–316 Occurrence Handle12667800 Occurrence Handle10.1016/S0042-6822(02)00095-8 Occurrence Handle1:CAS:528:DC%2BD3sXit1Kmu7k%3D

    Article  PubMed  CAS  Google Scholar 

  • J Wang H Jiang F Liu (2000) ArticleTitle In vitro selection of novel RNA ligands that bind human cytomegalovirus and block viral infection RNA 6 571–583 Occurrence Handle10786848 Occurrence Handle10.1017/S1355838200992215 Occurrence Handle1:CAS:528:DC%2BD3cXivFyjsLw%3D

    Article  PubMed  CAS  Google Scholar 

  • JM Whitcomb SH Huges (1992) ArticleTitleRetroviral reverse transcription and integration: progress and problems Annu Rev Cell Biol 8 275–306 Occurrence Handle1282352 Occurrence Handle10.1146/annurev.cb.08.110192.001423 Occurrence Handle1:CAS:528:DyaK3sXjtlKjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JR Wyatt TA Vickers JL Roberson RW Buckhett T Klimkait E DeBaets PW Davis B Rayner JL Imbach DJ Ecker (1994) ArticleTitleCombinatorial selected guanosine-quatret structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion Proc Natl Acad Sci USA 91 1356–1360 Occurrence Handle7906414 Occurrence Handle10.1073/pnas.91.4.1356 Occurrence Handle1:CAS:528:DyaK2cXis1Glsrc%3D

    Article  PubMed  CAS  Google Scholar 

  • R Yamamoto M Katahira S Nishikawa K Taira PKR Kumar (2000) ArticleTitleA novel RNA motif that binds efficiently and specifically to the Tat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo Genes Cells 5 371–388 Occurrence Handle10886365 Occurrence Handle10.1046/j.1365-2443.2000.00330.x Occurrence Handle1:CAS:528:DC%2BD3cXltVGhsrk%3D

    Article  PubMed  CAS  Google Scholar 

  • R Yamamoto K Murakami K Taira PKR Kumar (1998) ArticleTitleIsolation and characterization of an RNA that binds with high affinity to Tat protein of HIV-1 from a completely random pool of RNA Gene Thera Mol Biol 1 451–466

    Google Scholar 

  • R Yomamoto-Fujita PKR Kumar (2005) ArticleTitleAptamer-derived nucleic acid oligos: applications to develop nucleic acid chips to analyze proteins and small ligands Anal Chem 77 5460–5466 Occurrence Handle10.1021/ac050364f Occurrence Handle1:CAS:528:DC%2BD2MXmslemurc%3D

    Article  CAS  Google Scholar 

  • M Yamashita M Krystal WM Fitch P Palese (1988) ArticleTitleInfluenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses Virology 163 112–122 Occurrence Handle3267218 Occurrence Handle10.1016/0042-6822(88)90238-3 Occurrence Handle1:CAS:528:DyaL1cXlt1ehu78%3D

    Article  PubMed  CAS  Google Scholar 

  • W Yao K Adelman JA Bruenn (1997) ArticleTitle In vitro selection of packaging sites in a double-stranded RNA virus J Virol 71 2157–2162 Occurrence Handle9032349 Occurrence Handle1:CAS:528:DyaK2sXht1Wlurw%3D

    PubMed  CAS  Google Scholar 

  • F Zhang D Anderson (1998) ArticleTitle In vitro selection of bacteriophage phi29 prohead RNA aptamers for prohead binding J Biol Chem 273 2947–2953 Occurrence Handle9446607 Occurrence Handle10.1074/jbc.273.5.2947 Occurrence Handle1:CAS:528:DyaK1cXnvFSrsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

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  1. Functional Nucleic Acids Group, Institute for Biological Resources and Functions and Center for Applied Near Field Optics Research (CAN-FOR), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

    S. C. B. Gopinath

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Gopinath, S. Antiviral aptamers. Arch Virol 152, 2137–2157 (2007). https://doi.org/10.1007/s00705-007-1014-1

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