Summary.
Striatal dopamine reuptake sites were studied in brain samples from 14 Alzheimer's disease (AD) patients. A cocaine analogue, [3H]CFT (WIN 35,428, 2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) was used as a radioligand to determine the number of [3H]CFT binding sites (Bmax) and their dissociation constant (Kd). In patients with AD the reduction in [3H]CFT binding in the putamen was about 50% compared to age-matched controls. In the caudate nucleus the reduction was about 33%. Thus, the putamen was more severely affected. No change was observed in Kd values between AD patients and controls.
Brain samples from 37 healthy controls (aged from 8 to 91 years) were used to study the changes in striatal [3H]CFT binding with increasing age. The Bmax of [3H]CFT uptake was reduced both in the putamen and in the caudate nucleus. The average decline per decade was greater in the caudate nucleus (7.3%) than in the putamen (5.5%). In conclusion, the pattern of changes in AD is different from that seen during normal ageing, which seems to affect more severely the caudate nucleus than the putamen.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received June 26, 2000; accepted January 8, 2001
Rights and permissions
About this article
Cite this article
Kemppainen, N., Marjamäki, P., Röyttä, M. et al. Different pattern of reduction of striatal dopamine reuptake sites in Alzheimer's disease and ageing. J Neural Transm 108, 827–836 (2001). https://doi.org/10.1007/s007020170032
Issue Date:
DOI: https://doi.org/10.1007/s007020170032