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The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms

  • High Impact Review in Neuroscience, Neurology or Psychiatry - Review Article
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Abstract

Sleep disorders are among the most common clinical problems and possess a significant concern for the geriatric population. More importantly, while around 40% of elderly adults have sleep-related complaints, sleep disorders are more frequently associated with co-morbidities including age-related neurodegenerative diseases and mild cognitive impairment. Recently, increasing evidence has indicated that disturbed sleep may not only serve as the consequence of brain atrophy, but also contribute to the pathogenesis of dementia and, therefore, significantly increase dementia risk. Since the current therapeutic interventions lack efficacies to prevent, delay or reverse the pathological progress of dementia, a better understanding of underlying mechanisms by which sleep disorders interact with the pathogenesis of dementia will provide possible targets for the prevention and treatment of dementia. In this review, we briefly describe the physiological roles of sleep in learning/memory, and specifically update the recent research evidence demonstrating the association between sleep disorders and dementia. Plausible mechanisms are further discussed. Moreover, we also evaluate the possibility of sleep therapy as a potential intervention for dementia.

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Acknowledgements

This work was supported by funding from the National Natural Sciences Foundation of China (NSFC 81430021 and 81370470), the Scientific Research Fund of Liaoning. Provincial Education Department (L2015145), the Program for Liaoning Innovative Research Team in University (LT2015009) and Liaoning Science and Technology Project (2015225008).

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    Authors and Affiliations

    1. Liaoning Provincial Clinical Research Center for Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China

      Feng Zhang, Rujia Zhong, Song Li & Weidong Le

    2. Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China

      Feng Zhang, Rujia Zhong, Song Li & Weidong Le

    3. Laboratory of Neurodegenerative Diseases, LKS Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China

      Raymond Chuen-Chung Chang

    4. Collaborative Innovation Center for Brain Science, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China

      Weidong Le

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    1. Feng Zhang
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    2. Rujia Zhong
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    3. Song Li
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    4. Raymond Chuen-Chung Chang
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    5. Weidong Le
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    Correspondence to Weidong Le.

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    F. Zhang and R. Zhong contributed equally to this review.

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    Zhang, F., Zhong, R., Li, S. et al. The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms. J Neural Transm 124, 559–568 (2017). https://doi.org/10.1007/s00702-017-1696-9

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    • DOI: https://doi.org/10.1007/s00702-017-1696-9

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