Abstract
Professor Jellinger first identified that striatal Aβ deposition at postmortem seemed to differentiate cases of dementia with Lewy bodies (DLB) from those with Parkinson’s disease dementia (PDD), a finding subsequently questioned. Our replication study in 34 prospectively studied cases assessed the ability of striatal Aβ deposition to differentiate DLB from PDD, and also assessed the relationship between striatal and cortical Aβ deposition and α-synuclein-immunoreactive pathologies, using previously published protocols. Cases with DLB had significantly shorter durations and greater dementia severities compared with cases with PDD. Striatal Aβ-immunoreactive plaques were only consistently found in cases with DLB and correlated with both the severity (positive correlation) and duration (negative correlation) of dementia. Striatal Aβ-immunoreactive plaques also positively correlated with the severity of α-synuclein-immunoreactive pathologies as well as cortical Aβ-positive plaques. Striatal Aβ deposition positively predicted dementia in Lewy body cases with high specificity and had the greatest sensitivity to differentiate DLB from PDD with 100% negative predictive value. These data suggest that striatal Aβ deposition in Lewy body diseases contributes to early dementia and in these cases may impact on the efficacy of treatments targeting the striatum.
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Acknowledgments
The authors are grateful to the participants and their clinicians, to Heather McCann for diagnostic tissue preparation and histological processing, and to Heidi Cartwright for figure work. This work was supported by the National Health and Medical Research Council of Australia, the Ian Potter and Clive and Vera Ramaciotti Foundations, and Parkinson’s New South Wales Inc.
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Halliday, G.M., Song, Y.J.C. & Harding, A.J. Striatal β-amyloid in dementia with Lewy bodies but not Parkinson’s disease. J Neural Transm 118, 713–719 (2011). https://doi.org/10.1007/s00702-011-0641-6
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DOI: https://doi.org/10.1007/s00702-011-0641-6