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Impact of regional striatal dopaminergic function on kinematic parameters of Parkinson’s disease

Journal of Neural Transmission volume 122, pages 669–677 (2015)Cite this article

Abstract

Among the cardinal parkinsonian motor deficits, the severity of bradykinesia correlates with striatal dopamine loss. However, the impact of regional striatal dopamine loss on specific components of bradykinesia remains unknown. Using gyroscopes, we measured the amplitude, speed, and frequency of finger tapping in 24 untreated patients with Parkinson’s disease (PD) and 28 healthy controls. Using positron emission tomography (PET) studies and [18F]-N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (FP-CIT) in PD patients, we investigated the relationship between the mean values, variability and decrements of various kinematic parameters of finger tapping on one side (e.g. the mean, variability and decrement) and contralateral striatal FP-CIT binding. Compared with controls, PD patients had reduced amplitudes and speeds of tapping and showed greater decrement in those parameters. PD patients also exhibited greater irregularity in amplitude, speed, and frequency. Putaminal FP-CIT uptake levels correlated with the mean speed and amplitude, and caudate uptake levels correlated with mean amplitude. The variability of amplitude and speed correlated only with the caudate uptake levels. Neither caudate nor putaminal uptake correlated with frequency-related parameters or decrement in amplitude or speed. Reduced amplitude and speed of repetitive movement may be related to striatal dopaminergic deficit. Dopaminergic action in the caudate nucleus is required to maintain consistency of amplitude and speed. Although decrement of amplitude and speed is known to be specific for PD, we found that it did not mirror the degree of striatal dopamine depletion.

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Acknowledgments

This work was supported by a faculty grant from the Yonsei University College of Medicine (Grant Number 6-2010-0016).

Conflict of interest

The authors have no conflicts to disclose.

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Affiliations

  1. Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea

    Myung Jun Lee

  2. Department of Neurology, Gangnam Severance Hospital, Yonsei University of College of Medicine, 712 Eonju-ro, Gangnam-gu, Seoul, Republic of Korea

    Myung Jun Lee, Sha-Lom Kim, Chul Hyoung Lyoo & Myung-Sik Lee

  3. PET Center, University of Turku, Turku, Finland

    J. O. Rinne

Authors
  1. Myung Jun Lee
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  2. Sha-Lom Kim
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  3. Chul Hyoung Lyoo
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  4. J. O. Rinne
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Correspondence to Myung-Sik Lee.

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Supplementary material 1 (PNG 18 kb)

Supplementary Fig. 2

Scatter plots showing the correlation between the kinematic parameters of one side and contralateral FP-CIT uptake A. Correlations between parameters and caudate FP-CIT uptake B. Correlation between parameters and putaminal FP-CIT uptake (open circle = more-affected side; filled circle = less-affected side; R = Pearson’s correlation coefficient). Supplementary material 2 (TIFF 1,206 kb)

Supplementary material 3 (DOCX 15 kb)

Supplementary material 4 (DOCX 16 kb)

Supplementary material 5 (DOCX 17 kb)

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Lee, M.J., Kim, SL., Lyoo, C.H. et al. Impact of regional striatal dopaminergic function on kinematic parameters of Parkinson’s disease. J Neural Transm 122, 669–677 (2015). https://doi.org/10.1007/s00702-014-1296-x

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  • DOI: https://doi.org/10.1007/s00702-014-1296-x

Keywords

  • FP-CIT PET
  • Finger tapping
  • Kinematic analysis
  • Parkinson’s disease