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Prospective study on association between plasma amyloid beta-42 and atherosclerotic risk factors

  • Dementias - Original Article
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Abstract

An association between plasma Amyloid beta peptides (Aβ) with blood lipids was reported in cross-sectional studies. The present study examined the 5-year prospective association of atherosclerotic risk factors with plasma Aβ42 in 440 elderly persons without both Alzheimer’s disease (AD) or mild cognitive impairment (MCI) at baseline. Persons in the highest tertile of total cholesterol (TC) or LDL-C at baseline showed low plasma Aβ42 at 5 years. Regression analysis confirmed TC and LDL-C as negative predictors of Aβ42 (p = 0.001). An increase over 5 years of HDL-C was a negative predictor and the presence of an APOE ε4 allele was a positive predictor for decrease of Aβ42 in converters to MCI. In converters to AD, increase of both TC and of HbA1c were positive predictors of Aβ42 levels at 5 years. Analysis of covariance showed a positive association between Δ-TC, Δ-LDL-C, Δ-HbA1c, and levels of Aβ42 at 5 years (p = 0.006; 0.013 and 0.027 resp.) in converters to AD independently on lipid-lowering treatment. The association of vascular risk factors TC, LDL-C, and HbA1c with higher Aβ42 levels might, after confirmation in other cohorts, influence the development of lifestyle interventions concerning plasma Aβ42 and AD.

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Acknowledgments

We acknowledge the funding and organization of the Vienna Transdanube Aging (VITA) study by the Ludwig Boltzmann Society, Ludwig Boltzmann Institute of Aging Research (head: Prof. Karl-Heinz Tragl), P. Bauer for statistical advice in planning of the VITA study, W. Kirchmeyr and S. Torma for medical exploration of subjects and H. Hinterhuber for continuous support of our work.

Conflict of interest

All authors of this manuscript declare no conflict of interest.

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Authors and Affiliations

  1. Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria

    Imrich Blasko & Georg Kemmler

  2. Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria

    Susanne Jungwirth, Silvia Weissgram, Karl Heinz Tragl & Peter Fischer

  3. Institute of Clinical Neurobiology, Vienna, Austria

    Ildiko Wichart & Kurt Jellinger

  4. Danube Hospital, Vienna, Austria

    Karl Heinz Tragl

  5. Department of Psychiatry, Medical Research Society, Danube Hospital, Vienna, Austria

    Peter Fischer

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  1. Imrich Blasko
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  2. Georg Kemmler
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  5. Silvia Weissgram
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  7. Karl Heinz Tragl
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  8. Peter Fischer
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Correspondence to Imrich Blasko.

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Blasko, I., Kemmler, G., Jungwirth, S. et al. Prospective study on association between plasma amyloid beta-42 and atherosclerotic risk factors. J Neural Transm 118, 663–672 (2011). https://doi.org/10.1007/s00702-011-0599-4

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  • DOI: https://doi.org/10.1007/s00702-011-0599-4

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