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Inflammation in neuroviral diseases

  • Basic Neurosciences, Genetics and Immunology - Review Article
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Abstract

During any viral infection of the central nervous system (CNS), the extent and nature of neural cell alterations are dictated by the localization of virus replication and, possibly, persistence. However, one additional source of CNS damage comes from the immune response that develops following CNS viral infection. Indeed, despite of its major role in controlling virus spread in the infected CNS, the immune system is equipped with numerous molecular effectors shared with the nervous system that may greatly alter the homeostasis and function of neural cells. Proinflammatory cytokines and metalloproteases belong to this inflammatory cascade. Besides neurovirulence, the crosstalk engaged between neural and immune cells is a major factor determining the outcome of neuroviral infections.

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Acknowledgments

We particularly thank Dr. Serge Nataf (U842 Inserm) for help in writing manuscript and helpful discussions. The French Association of Research on multiple sclerosis ARSEP has supported the work cited in this review.

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  1. Inserm, U842, Lyon, France

    Pascale Giraudon & Arlette Bernard

  2. UMR-S842, Université de Lyon, Lyon, France

    Pascale Giraudon & Arlette Bernard

  3. Faculty of Medicine Laennec, Rue Guillaume Paradin, 69372, Lyon, France

    Pascale Giraudon & Arlette Bernard

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  1. Pascale Giraudon
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Correspondence to Pascale Giraudon.

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Giraudon, P., Bernard, A. Inflammation in neuroviral diseases. J Neural Transm 117, 899–906 (2010). https://doi.org/10.1007/s00702-010-0402-y

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