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Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans

  • Basic Neurosciences, Genetics and Immunology - Short Communication
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Abstract

Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 μg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.

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Authors and Affiliations

  1. Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci, 14-43100, Parma, Italy

    Vittorio Coiro, Pasquale Rubino, Guido Manfredi & Paola Vacca

  2. Department of Public Health, University of Parma, Parma, Italy

    Gloria Saccani-Jotti

  3. Graduate School in Physical Exercise and Sport Sciences, University of Parma, Parma, Italy

    Elio Volta & Paolo Chiodera

Authors
  1. Vittorio Coiro
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  2. Gloria Saccani-Jotti
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  3. Pasquale Rubino
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  4. Guido Manfredi
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  5. Paola Vacca
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  6. Elio Volta
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  7. Paolo Chiodera
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Correspondence to Vittorio Coiro.

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Coiro, V., Saccani-Jotti, G., Rubino, P. et al. Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans. J Neural Transm 115, 1265–1267 (2008). https://doi.org/10.1007/s00702-008-0057-0

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  • DOI: https://doi.org/10.1007/s00702-008-0057-0

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