Skip to main content
SpringerLink
Log in

Effects of aripiprazole and terguride on dopamine synthesis in the dorsal striatum and medial prefrontal cortex of preweanling rats

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

The purpose of this study was to determine whether aripiprazole, a D2-like partial agonist increasingly prescribed to children, alters DA synthesis via actions at autoreceptors in the dorsal striatum and medial prefrontal cortex (mPFC) of preweanling rats. The ability of dopaminergic agents to alter DOPA accumulation in the striatum and mPFC was measured after NSD-1015 on postnatal day (PD) 20. Dopaminergic tone was manipulated by administering reserpine, γ-butyrolactone (GBL), or through amphetamine withdrawal. Results showed that the partial agonists aripiprazole and terguride increased striatal DOPA accumulation under normosensitive conditions, but decreased DOPA accumulation in states of low dopaminergic tone. A different pattern of results was observed in the mPFC, because terguride and haloperidol, but not aripiprazole, increased DOPA accumulation under normosensitive conditions. In conclusion, the present data show that aripiprazole affects striatal synthesis modulating autoreceptors in an adult-typical manner during the late preweanling period. Unlike in adult rats, however, the mPFC of preweanling rats appears to contain transitory synthesis modulating autoreceptors that are sensitive to drug manipulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • SL Andersen (2003) ArticleTitleTrajectories of brain development: point of vulnerability or window of opportunity Neurosci Biobehav Rev 27 3–18 Occurrence Handle12732219 Occurrence Handle10.1016/S0149-7634(03)00005-8

    Article  PubMed  Google Scholar 

  • SL Andersen RA Gazzara (1993) ArticleTitleThe ontogeny of apomorphine-induced alterations of neostriatal dopamine release: effects on spontaneous release J Neurochem 61 2247–2255 Occurrence Handle8245975 Occurrence Handle10.1111/j.1471-4159.1993.tb07466.x Occurrence Handle1:CAS:528:DyaK2cXksFOltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SL Andersen RA Gazzara (1994) ArticleTitleThe development of D2 autoreceptor-mediated modulation of K(+)-evoked dopamine release in the neostriatum Dev Brain Res 78 123–130 Occurrence Handle10.1016/0165-3806(94)90016-7 Occurrence Handle1:CAS:528:DyaK2cXitV2itLk%3D

    Article  CAS  Google Scholar 

  • SL Andersen NL Dumont MH Teicher (1997) ArticleTitleDevelopmental differences in dopamine synthesis inhibition by (±)-7-OH-DPAT Naunyn Schmiedebergs Arch Pharmacol 356 173–181 Occurrence Handle9272722 Occurrence Handle10.1007/PL00005038 Occurrence Handle1:CAS:528:DyaK2sXkslGms7s%3D

    Article  PubMed  CAS  Google Scholar 

  • RJ Baldessarini ER Marsh D Huston-Lyons (1994) ArticleTitleEffects of dopamine partial-agonist aminoergolines on dopamine metabolism in limbic and extrapyramidal regions of rat brain Biochem Pharmacol 47 1917–1919 Occurrence Handle7911303 Occurrence Handle10.1016/0006-2952(94)90323-9 Occurrence Handle1:CAS:528:DyaK2cXksV2qtb4%3D

    Article  PubMed  CAS  Google Scholar 

  • MJ Bannon RL Michaud RH Roth (1981) ArticleTitleMesocortical dopamine neurons: lack of autoreceptors modulating dopamine synthesis Mol Pharmacol 19 270–275 Occurrence Handle6785571 Occurrence Handle1:CAS:528:DyaL3MXhvV2hsrs%3D

    PubMed  CAS  Google Scholar 

  • AM Barr AG Phillips (1999) ArticleTitleWithdrawal following repeated exposure to d-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement Psychopharmacology 141 99–106 Occurrence Handle9952071 Occurrence Handle10.1007/s002130050812 Occurrence Handle1:CAS:528:DyaK1MXhtFygu7c%3D

    Article  PubMed  CAS  Google Scholar 

  • DH Barzman MP DelBello RA Kowatch B Gernert DE Fleck S Pathak K Rappaport SV Delgado P Campbell SM Strakowski (2004) ArticleTitleThe effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review J Child Adolesc Psychopharmacol 14 593–600 Occurrence Handle15662152 Occurrence Handle10.1089/cap.2004.14.593

    Article  PubMed  Google Scholar 

  • J Biederman MA McDonnell J Wozniak T Spencer M Aleardi R Falzone E Mick (2005) ArticleTitleAripiprazole in the treatment of pediatric bipolar disorder: a systematic chart review CNS Spectr 10 141–148 Occurrence Handle15685125

    PubMed  Google Scholar 

  • T Brucke W Danielczyk M Simanyi E Sofic P Riederer (1987) ArticleTitleTerguride: partial dopamine agonist in the treatment of Parkinson’s disease Adv Neurol 45 573–576 Occurrence Handle3825735 Occurrence Handle1:STN:280:DyaL2s7lt1Oisg%3D%3D

    PubMed  CAS  Google Scholar 

  • KD Burris TF Molski C Xu E Ryan K Tottori T Kikuchi FD Yocca PB Molinoff (2002) ArticleTitleAripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors J Pharmacol Exp Ther 302 381–389 Occurrence Handle12065741 Occurrence Handle10.1124/jpet.102.033175 Occurrence Handle1:CAS:528:DC%2BD38Xlt1SnsLY%3D

    Article  PubMed  CAS  Google Scholar 

  • A Byars K Burris S Jordan K Tottori T Kikuchi R McQuade (2002) ArticleTitleAripiprazole: a dopamine-serotonin system stabilizer Eur Neuropsychopharmacol 12 IssueIDSuppl 3 S290–S291 Occurrence Handle10.1016/S0924-977X(02)80412-6

    Article  Google Scholar 

  • A Carlsson (1983) ArticleTitleDopamine receptor agonists: intrinsic activity vs. state of the receptor J Neural Transm 57 309–315 Occurrence Handle6418858 Occurrence Handle10.1007/BF01249001 Occurrence Handle1:CAS:528:DyaL2cXmt1eruw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • D Clark S Hjorth A Carlsson (1985a) ArticleTitle(+)- and (−)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis Eur J Pharmacol 106 185–189 Occurrence Handle10.1016/0014-2999(84)90694-0

    Article  Google Scholar 

  • D Clark S Hjorth A Carlsson (1985b) ArticleTitleDopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations J Neural Transm 62 171–207 Occurrence Handle10.1007/BF01252236 Occurrence Handle1:CAS:528:DyaL2MXlvVyqsbo%3D

    Article  CAS  Google Scholar 

  • D Clark RS Salah MP Galloway (1991) ArticleTitleDifferential agonist profile of the enantiomers of 3-PPP at striatal dopamine autoreceptors: dependence on extracellular dopamine Synapse 8 169–176 Occurrence Handle1948667 Occurrence Handle10.1002/syn.890080304 Occurrence Handle1:CAS:528:DyaK3MXlslCntb8%3D

    Article  PubMed  CAS  Google Scholar 

  • GU Corsini U Bonuccelli E Rainer M Del Zompo (1985) ArticleTitleTherapeutic efficacy of a partial dopamine agonist in drug-free parkinsonian patients J Neural Transm 64 105–111 Occurrence Handle4078566 Occurrence Handle10.1007/BF01245972 Occurrence Handle1:STN:280:DyaL28%2Fosl2jsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • P Critchley D Parkes (1987) ArticleTitleTransdihydrolisuride in parkinsonism Clin Neuropharmacol 10 57–64 Occurrence Handle3815388 Occurrence Handle10.1097/00002826-198702000-00005 Occurrence Handle1:STN:280:DyaL2s7jtVyjsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • MA Davies DJ Sheffler BL Roth (2004) ArticleTitleAripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology CNS Drug Rev 10 317–336 Occurrence Handle15592581 Occurrence Handle1:CAS:528:DC%2BD2MXhsFejsLo%3D Occurrence Handle10.1111/j.1527-3458.2004.tb00030.x

    Article  PubMed  CAS  Google Scholar 

  • F Fadda GL Gessa M Marcou E Mosca Z Rossetti (1984) ArticleTitleEvidence for dopamine autoreceptors in mesocortical dopamine neurons Brain Res 293 67–72 Occurrence Handle6423212 Occurrence Handle10.1016/0006-8993(84)91453-7 Occurrence Handle1:CAS:528:DyaL2cXpslakug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CM Farley SA Baella JJ Wacan CA Crawford SA McDougall (2006) ArticleTitlePre- and postsynaptic actions of a partial D2 receptor agonist in reserpinized young rats: longevity of agonistic effects Brain Res 1124 37–44 Occurrence Handle17070785 Occurrence Handle10.1016/j.brainres.2006.09.068 Occurrence Handle1:CAS:528:DC%2BD28Xht1eksrjE

    Article  PubMed  CAS  Google Scholar 

  • MW Feltenstein CA Altar RE See (2007) ArticleTitleAripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse Biol Psychiatry 61 582–590 Occurrence Handle16806092 Occurrence Handle10.1016/j.biopsych.2006.04.010 Occurrence Handle1:CAS:528:DC%2BD2sXhvVynu74%3D

    Article  PubMed  CAS  Google Scholar 

  • RL Findling J Blumer R Kauffman J Batterson D Gilbert S Bramer R Marcus (2003) ArticleTitleAripiprazole in pediatric conduct disorder: a pilot study Eur Neuropsychopharm 13 IssueIDSuppl 4 S335 Occurrence Handle10.1016/S0924-977X(03)92080-3

    Article  Google Scholar 

  • MP Galloway ME Wolf RH Roth (1986) ArticleTitleRegulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: studies in vivo J Pharmacol Exp Ther 236 689–698 Occurrence Handle3081705 Occurrence Handle1:CAS:528:DyaL28XhvVSmtbo%3D

    PubMed  CAS  Google Scholar 

  • V Hillegaart O Magnusson S Ahlenius (2000) ArticleTitleA9 and A10 dopamine nuclei as a site of action for effects of 8-OH-DPAT on locomotion in the rat Pharmacol Biochem Behav 67 55–63 Occurrence Handle11113484 Occurrence Handle10.1016/S0091-3057(00)00292-6 Occurrence Handle1:CAS:528:DC%2BD3cXoslGns7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • S Hjorth A Carlsson D Clark K Svensson H Wikstrom D Sanchez P Lindberg U Hacksell LE Arvidsson A Johansson JLG Nilsson (1983) ArticleTitleCentral dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP Psychopharmacology 81 89–99 Occurrence Handle6415751 Occurrence Handle10.1007/BF00428999 Occurrence Handle1:CAS:528:DyaL3sXls12ns7g%3D

    Article  PubMed  CAS  Google Scholar 

  • S Hjorth D Clark A Carlsson (1988) ArticleTitleDopamine (DA) autoreceptor efficacy of 3-PPP enantiomers after short-term synaptic DA deprivation Eur J Pharmacol 152 207–215 Occurrence Handle3146512 Occurrence Handle10.1016/0014-2999(88)90715-7 Occurrence Handle1:CAS:528:DyaL1cXlt1aqtLY%3D

    Article  PubMed  CAS  Google Scholar 

  • ME Hoefer SJ Voskanian GF Koob L Pulvirenti (2006) ArticleTitleEffects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat Pharmacol Biochem Behav 83 403–409 Occurrence Handle16647107 Occurrence Handle10.1016/j.pbb.2006.02.023 Occurrence Handle1:CAS:528:DC%2BD28XltVektLs%3D

    Article  PubMed  CAS  Google Scholar 

  • M Huang Z Li J Ichikawa J Dai HY Meltzer (2006) ArticleTitleEffects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex Brain Res 1099 44–55 Occurrence Handle16824491 Occurrence Handle10.1016/j.brainres.2006.04.081 Occurrence Handle1:CAS:528:DC%2BD28XntlWitbs%3D

    Article  PubMed  CAS  Google Scholar 

  • CW Hughes (1979) ArticleTitleOutcome of early experience studies as affected by between-litters variance J Nutr 109 642–645 Occurrence Handle430265 Occurrence Handle1:STN:280:DyaE1M7ltlertA%3D%3D

    PubMed  CAS  Google Scholar 

  • S Jordan V Koprivica R Chen K Tottori T Kikuchi CA Altar (2002) ArticleTitleThe antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor Eur J Pharmacol 441 137–140 Occurrence Handle12063084 Occurrence Handle10.1016/S0014-2999(02)01532-7 Occurrence Handle1:CAS:528:DC%2BD38XksVSiurg%3D

    Article  PubMed  CAS  Google Scholar 

  • S Jordan V Koprivica R Dunn K Tottori T Kikuchi CA Altar (2004) ArticleTitleIn vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function Eur J Pharmacol 483 45–53 Occurrence Handle14709325 Occurrence Handle10.1016/j.ejphar.2003.10.025 Occurrence Handle1:CAS:528:DC%2BD2cXpt1ai

    Article  PubMed  CAS  Google Scholar 

  • PE Keck SuffixJr R Marcus S Tourkodimitris M Ali A Liebeskind A Saha G Ingenito (2003) ArticleTitleA placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania Am J Psychiatry 160 1651–1658 Occurrence Handle12944341 Occurrence Handle10.1176/appi.ajp.160.9.1651

    Article  PubMed  Google Scholar 

  • W Kehr (1984) ArticleTitleTransdihydrolisuride, a partial dopamine receptor antagonist: Effects on monoamine metabolism Eur J Pharmacol 97 111–119 Occurrence Handle6421606 Occurrence Handle10.1016/0014-2999(84)90518-1 Occurrence Handle1:CAS:528:DyaL2cXps1Klsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • T Kikuchi K Tottori Y Uwahodo T Hirose T Miwa Y Oshiro S Morita (1995) ArticleTitle7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity J Pharmacol Exp Ther 274 329–336 Occurrence Handle7616416 Occurrence Handle1:CAS:528:DyaK2MXntVWlt7c%3D

    PubMed  CAS  Google Scholar 

  • T Kuroki J Dai HY Meltzer J Ichikawa (2000) ArticleTitleR(+)-8-OH-DPAT, a selective 5-HT1A receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex Brain Res 872 204–207 Occurrence Handle10924694 Occurrence Handle10.1016/S0006-8993(00)02437-9 Occurrence Handle1:CAS:528:DC%2BD3cXltlektLo%3D

    Article  PubMed  CAS  Google Scholar 

  • CP Lawler C Prioleau MM Lewis C Mak D Jiang JA Schetz AM Gonzalez DR Sibley (1999) ArticleTitleInteractions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes Neuropsychopharmacology 20 612–627 Occurrence Handle10327430 Occurrence Handle10.1016/S0893-133X(98)00099-2 Occurrence Handle1:CAS:528:DyaK1MXjsVamu7c%3D

    Article  PubMed  CAS  Google Scholar 

  • Z Li J Ichikawa J Dai HY Meltzer (2004) ArticleTitleAripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain Eur J Pharmacol 493 75–83 Occurrence Handle15189766 Occurrence Handle10.1016/j.ejphar.2004.04.028 Occurrence Handle1:CAS:528:DC%2BD2cXkvV2htr0%3D

    Article  PubMed  CAS  Google Scholar 

  • E Meller K Bohmaker Y Namba AJ Friedhoff M Goldstein (1987) ArticleTitleRelationship between receptor occupancy and response at striatal autoreceptors Mol Pharmacol 31 592–598 Occurrence Handle2885734 Occurrence Handle1:CAS:528:DyaL2sXkslWgtLo%3D

    PubMed  CAS  Google Scholar 

  • MJ Millan L Maiofiss D Cussac V Audinot J-A Boutin A Newman-Tancredi (2002) ArticleTitleDifferential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J Pharmacol Exp Ther 303 791–804 Occurrence Handle12388666 Occurrence Handle10.1124/jpet.102.039867 Occurrence Handle1:CAS:528:DC%2BD38XotlCnsL8%3D

    Article  PubMed  CAS  Google Scholar 

  • TK Murphy MA Bengtson O Soto PJ Edge MW Sajid N Shapira M Yang (2005) ArticleTitleCase series on the use of aripiprazole for Tourette syndrome Int J Neuropsychopharmacol 8 489–490 Occurrence Handle15857570 Occurrence Handle10.1017/S1461145705005365 Occurrence Handle1:CAS:528:DC%2BD2MXlsFams7g%3D

    Article  PubMed  CAS  Google Scholar 

  • A Newman-Tancredi D Cussac V Audinot JP Nicolas F De Ceuninck J-A Boutin MJ Millan (2002a) ArticleTitleDifferential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor J Pharmacol Exp Ther 303 805–814 Occurrence Handle10.1124/jpet.102.039875 Occurrence Handle1:CAS:528:DC%2BD38XotlCnsLw%3D

    Article  CAS  Google Scholar 

  • A Newman-Tancredi D Cussac Y Quentric M Touzard L Verrièle N Carpentier MJ Millan (2002b) ArticleTitleDifferential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT1 and 5-HT2, receptor subtypes J Pharmacol Exp Ther 303 815–822 Occurrence Handle10.1124/jpet.102.039883 Occurrence Handle1:CAS:528:DC%2BD38XotlCnsL0%3D

    Article  CAS  Google Scholar 

  • C Orsini GF Koob L Pulvirenti (2001) ArticleTitleDopamine partial agonist reverses amphetamine withdrawal in rats Neuropsychopharmacology 25 789–792 Occurrence Handle11682262 Occurrence Handle10.1016/S0893-133X(01)00270-6 Occurrence Handle1:CAS:528:DC%2BD3MXnslCjtrw%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Oshiro S Sato N Kurahashi T Tanaka T Kikuchi K Tottori Y Uwahodo T Nishi (1998) ArticleTitleNovel antipsychotic agents with dopamine autoreceptor agonist properties: synthesis and pharmacology of 7-[4-(4-phenyl-1-piperazinyl)butoxy]-3,4-dihydro-2(1H)-quinolinone derivatives J Med Chem 41 658–667 Occurrence Handle9513593 Occurrence Handle10.1021/jm940608g Occurrence Handle1:CAS:528:DyaK1cXosFaqtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • DM Platt JS Rodefer JK Rowlett RD Spealman (2003) ArticleTitleSuppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys Psychopharmacology 166 298–305 Occurrence Handle12589523 Occurrence Handle1:CAS:528:DC%2BD3sXitFGmtLk%3D

    PubMed  CAS  Google Scholar 

  • L Pulvirenti GF Koob (1994) ArticleTitleDopamine receptor agonists, partial agonists and psychostimulant addiction Trends Pharmacol Sci 15 374–379 Occurrence Handle7809953 Occurrence Handle10.1016/0165-6147(94)90158-9 Occurrence Handle1:CAS:528:DyaK2MXitVCrtbk%3D

    Article  PubMed  CAS  Google Scholar 

  • TA Rugino YM Janvier (2005) ArticleTitleAripiprazole in children and adolescents: clinical experience J Child Neurol 20 603–610 Occurrence Handle16159529

    PubMed  Google Scholar 

  • K Schwabe M Koch (2007) ArticleTitleEffects of aripiprazole on operant responding for a natural reward after psychostimulant withdrawal in rats Psychopharmacology 191 759–765 Occurrence Handle16953383 Occurrence Handle10.1007/s00213-006-0520-2 Occurrence Handle1:CAS:528:DC%2BD2sXitlCqtLo%3D

    Article  PubMed  CAS  Google Scholar 

  • J Semba A Watanabe S Kito M Toru (1995) ArticleTitleBehavioural and neurochemical effects of OPC-14597, a novel antipsychotic drug, on dopaminergic mechanisms in rat brain Neuropharmacology 34 785–791 Occurrence Handle8532145 Occurrence Handle10.1016/0028-3908(95)00059-F Occurrence Handle1:CAS:528:DyaK2MXns1ynt74%3D

    Article  PubMed  CAS  Google Scholar 

  • IA Shalaby PS Dendel LP Spear (1981) ArticleTitleDifferential functional ontogeny of dopamine presynaptic receptor regulation Brain Res 227 434–439 Occurrence Handle7260651 Occurrence Handle1:STN:280:DyaL3M3lsl2itw%3D%3D

    PubMed  CAS  Google Scholar 

  • DA Shapiro S Renock E Arrington LA Chiodo LX Liu DR Sibley BL Roth R Mailman (2003) ArticleTitleAripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology Neuropsychopharmacology 28 1400–1411 Occurrence Handle12784105 Occurrence Handle10.1038/sj.npp.1300203 Occurrence Handle1:CAS:528:DC%2BD3sXls1Slsro%3D

    Article  PubMed  CAS  Google Scholar 

  • JM Stachnik C Nunn-Thompson (2007) ArticleTitleUse of atypical antipsychotics in the treatment of autistic disorder Ann Pharmacother 41 626–634 Occurrence Handle17389666 Occurrence Handle10.1345/aph.1H527 Occurrence Handle1:CAS:528:DC%2BD2sXltlOnsrg%3D

    Article  PubMed  CAS  Google Scholar 

  • AD Stark S Jordan KA Allers RL Bertekap R Chen TM Kannan TF Molski FD Yocca T Sharp T Kikuchi KD Burris (2007) ArticleTitleInteraction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies Psychopharmacology 190 373–382 Occurrence Handle17242925 Occurrence Handle10.1007/s00213-006-0621-y Occurrence Handle1:CAS:528:DC%2BD2sXosFGqtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • KA Stigler DJ Posey CJ McDougle (2004) ArticleTitleAripiprazole for maladaptive behavior in pervasive developmental disorders J Child Adolesc Psychopharmacol 14 455–463 Occurrence Handle15650503 Occurrence Handle10.1089/cap.2004.14.455

    Article  PubMed  Google Scholar 

  • K Svensson A Ekman MF Piercey WE Hoffmann JT Lum A Carlsson (1991) ArticleTitleEffects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study Naunyn-Schmiedebergs Arch Pharmacol 344 263–274 Occurrence Handle1683686 Occurrence Handle1:CAS:528:DyaK3MXmslSms7o%3D

    PubMed  CAS  Google Scholar 

  • K Svensson E Eriksson A Carlsson (1993) ArticleTitlePartial dopamine receptor agonists reverse behavioral, biochemical and neuroendocrine effects of neuroleptics in the rat: potential treatment of extrapyramidal side effects Neuropharmacology 32 1037–1045 Occurrence Handle7905192 Occurrence Handle10.1016/0028-3908(93)90069-F Occurrence Handle1:CAS:528:DyaK2cXksFOjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JD Urban GA Vargas M von Zastrow RB Mailman (2007) ArticleTitleAripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways Neuropsychopharmacology 32 67–77 Occurrence Handle16554739 Occurrence Handle10.1038/sj.npp.1301071 Occurrence Handle1:CAS:528:DC%2BD28XhtlSqtbrJ

    Article  PubMed  CAS  Google Scholar 

  • JJ Wacan CM Reichel CM Farley SA McDougall (2006) ArticleTitleThe partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen Psychopharmacology 185 104–111 Occurrence Handle16447063 Occurrence Handle10.1007/s00213-005-0263-5 Occurrence Handle1:CAS:528:DC%2BD28XhslWnsrY%3D

    Article  PubMed  CAS  Google Scholar 

  • ST Yoshida SA Baella NM Stuebner CA Crawford SA McDougall (2006) ArticleTitleEffects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats Brain Res 1073/1074 269–275 Occurrence Handle10.1016/j.brainres.2005.12.054 Occurrence Handle1:CAS:528:DC%2BD28Xis1Sqt7c%3D

    Article  CAS  Google Scholar 

  • A Zocchi D Fabbri CA Heidbreder (2005) ArticleTitleAripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex Neurosci Lett 387 157–161 Occurrence Handle16023290 Occurrence Handle10.1016/j.neulet.2005.06.035 Occurrence Handle1:CAS:528:DC%2BD2MXosVaisLs%3D

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychology, California State University, San Bernardino, CA, USA

    S. D. Iñiguez, A. M. Cortez, C. A. Crawford & S. A. McDougall

Authors
  1. S. D. Iñiguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Cortez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. A. Crawford
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. McDougall
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. A. McDougall.

Additional information

Correspondence: Sanders A. McDougall, Department of Psychology, California State University, 5500 University Parkway, San Bernardino, CA 92407, USA

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iñiguez, S., Cortez, A., Crawford, C. et al. Effects of aripiprazole and terguride on dopamine synthesis in the dorsal striatum and medial prefrontal cortex of preweanling rats. J Neural Transm 115, 97–106 (2008). https://doi.org/10.1007/s00702-007-0820-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-007-0820-7

Search

Navigation