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Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain

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Summary.

The continuous intra-cortical infusion of a glia toxin, fluorocitrate, at the concentration of 1 mM caused a decrease in the cortical extracellular contents of an intrinsic coagonist for the N-methyl-D-aspartate (NMDA) type glutamate receptor, D-serine, by peaking at 40 min by −25% but produced an increase in those of glycine and L-serine. The attenuated glial activity by fluorocitrate was verified by a marked reduction in the extracellular glutamine contents. The present findings suggest that a group of glial cells such as a population of the protoplasmic astrocytes could, at least in part, participate differently in the regulation of the extracellular release of D-serine and another NMDA coagonist glycine in the medial frontal cortex of the rat.

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Authors and Affiliations

  1. Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

    S. Kanematsu, S. Ishii, A. Umino, T. Fujihira, A. Kashiwa, N. Yamamoto, A. Kurumaji & T. Nishikawa

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  1. S. Kanematsu
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  2. S. Ishii
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  3. A. Umino
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  4. T. Fujihira
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  5. A. Kashiwa
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  6. N. Yamamoto
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  7. A. Kurumaji
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  8. T. Nishikawa
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Kanematsu, S., Ishii, S., Umino, A. et al. Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain. J Neural Transm 113, 1717–1721 (2006). https://doi.org/10.1007/s00702-006-0517-3

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  • DOI: https://doi.org/10.1007/s00702-006-0517-3

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