Summary.
Functional magnetic resonance imaging (fMRI) is presently either performed using blood oxygenation level-dependent (BOLD) contrast or using cerebral blood flow (CBF), measured with arterial spin labeling (ASL) technique. The present fMRI study aimed to provide practical hints to favour one method over the other. It involved three different acquisition methods during visual checkerboard stimulation on nine healthy subjects: 1) CBF contrast obtained from ASL, 2) BOLD contrast extracted from ASL and 3) BOLD contrast from Echo planar imaging. Previous findings were replicated; i) no differences between the three measurements were found in the location of the activated region; ii) differences were found in the temporal characteristics of the signals and iii) BOLD has significantly higher sensitivity than ASL perfusion. ASL fMRI was favoured when the investigation demands for perfusion and task related signal changes. BOLD fMRI is more suitable in conjunction with fast event related design.
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References
GK Aguirre JA Detre E Zarahn DC Alsop (2002) ArticleTitleExperimental design and the relative sensitivity of BOLD and perfusion fMRI Neuroimage 15 488–500 Occurrence Handle11848692 Occurrence Handle1:STN:280:DC%2BD387lsFOnsQ%3D%3D Occurrence Handle10.1006/nimg.2001.0990
DC Alsop JA Detre M Grossman (2000) ArticleTitleAssessment of cerebral blood flow in Alzheimer’s disease by spin-labeled magnetic resonance imaging Ann Neurol 47 93–100 Occurrence Handle10632106 Occurrence Handle1:STN:280:DC%2BD3c%2FpsF2ltQ%3D%3D Occurrence Handle10.1002/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO;2-8
AM Blamire S Ogawa K Ugurbil D Rothman G McCarthy JM Ellermann F Hyder Z Rattner RG Shulman (1992) ArticleTitleDynamic mapping of the human visual cortex by high-speed magnetic resonance imaging Proc Natl Acad Sci USA 89 11069–11073 Occurrence Handle1438317 Occurrence Handle1:STN:280:ByyD28njvVI%3D Occurrence Handle10.1073/pnas.89.22.11069
GM Boynton SA Engel GH Glover DJ Heeger (1996) ArticleTitleLinear systems analysis of functional magnetic resonance imaging in human V1 J Neurosci 16 4207–4221 Occurrence Handle8753882 Occurrence Handle1:CAS:528:DyaK28XjvVGktrs%3D
RB Buxton LR Frank EC Wong B Siewert S Warach RR Edelman (1998) ArticleTitleA general kinetic model for quantitative perfusion imaging with arterial spin labeling Magn Reson Med 40 383–396 Occurrence Handle9727941 Occurrence Handle1:STN:280:DyaK1czpsV2htg%3D%3D
RB Buxton K Uludag DJ Dubowitz TT Liu (2004) ArticleTitleModeling the hemodynamic response to brain activation Neuroimage 23 IssueID[Suppl 1] S220–S233 Occurrence Handle15501093 Occurrence Handle10.1016/j.neuroimage.2004.07.013
F Calamante DL Thomas GS Pell J Wiersma R Turner (1999) ArticleTitleMeasuring cerebral blood flow using magnetic resonance imaging techniques J Cereb Blood Flow Metab 19 701–735 Occurrence Handle10413026 Occurrence Handle1:STN:280:DyaK1MzjvFeksw%3D%3D Occurrence Handle10.1097/00004647-199907000-00001
W Chen K Ugurbil (1999) ArticleTitleHigh spatial resolution functional magnetic resonance imaging at very-high-magnetic field Top Magn Reson Imaging 10 63–78 Occurrence Handle10389673 Occurrence Handle1:STN:280:DyaK1Mzhs1Ggtw%3D%3D
JA Detre DC Alsop (1999) ArticleTitlePerfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system Eur J Radiol 30 115–124 Occurrence Handle10401592 Occurrence Handle1:STN:280:DyaK1MzivFygtw%3D%3D Occurrence Handle10.1016/S0720-048X(99)00050-9
JA Detre JS Leigh DS Williams AP Koretsky (1992) ArticleTitlePerfusion imaging Magn Reson Med 23 37–45 Occurrence Handle1734182 Occurrence Handle1:STN:280:By2C3s%2FnvVw%3D
JA Detre J Wang (2002) ArticleTitleTechnical aspects and utility of fMRI using BOLD and ASL Clin Neurophysiol 113 621–634 Occurrence Handle11976042 Occurrence Handle10.1016/S1388-2457(02)00038-X
EA DeYoe P Bandettini J Neitz D Miller P Winans (1994) ArticleTitleFunctional magnetic resonance imaging (FMRI) of the human brain J Neurosci Methods 54 171–187 Occurrence Handle7869750 Occurrence Handle1:STN:280:ByqC2svjvV0%3D Occurrence Handle10.1016/0165-0270(94)90191-0
F Di Salle E Formisano DE Linden R Goebel S Bonavita A Pepino F Smaltino G Tedeschi (1999) ArticleTitleExploring brain function with magnetic resonance imaging Eur J Radiol 30 84–94 Occurrence Handle10401589 Occurrence Handle1:STN:280:DyaK1MzivFygsA%3D%3D Occurrence Handle10.1016/S0720-048X(99)00047-9
RF Dougherty VM Koch AA Brewer B Fischer J Modersitzki BA Wandell (2003) ArticleTitleVisual field representations and locations of visual areas V1/2/3 in human visual cortex J Vis 3 586–598 Occurrence Handle14640882 Occurrence Handle10.1167/3.10.1
CM Feng S Narayana JL Lancaster PA Jerabek TL Arnow F Zhu LH Tan PT Fox JH Gao (2004) ArticleTitleCBF changes during brain activation: fMRI vs. PET Neuroimage 22 443–446 Occurrence Handle15110037 Occurrence Handle10.1016/j.neuroimage.2004.01.017
PT Fox ME Raichle (1984) ArticleTitleStimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography J Neurophysiol 51 1109–1120 Occurrence Handle6610024 Occurrence Handle1:STN:280:DyaL2c3hsFaltQ%3D%3D
PT Fox ME Raichle (1985) ArticleTitleStimulus rate determines regional brain blood flow in striate cortex Ann Neurol 17 303–305 Occurrence Handle3873210 Occurrence Handle1:STN:280:DyaL2M7pslOiuw%3D%3D Occurrence Handle10.1002/ana.410170315
G Garraux M Hallett SL Talagala (2005) ArticleTitleCASL fMRI of subcortico-cortical perfusion changes during memory-guided finger sequences Neuroimage 25 122–132 Occurrence Handle15734349 Occurrence Handle10.1016/j.neuroimage.2004.11.004
JB Gonzalez-At DC Alsop JA Detre (2000) ArticleTitleCerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling Magn Reson Med 43 739–746 Occurrence Handle10800040 Occurrence Handle1:STN:280:DC%2BD3c3mtFOqsg%3D%3D Occurrence Handle10.1002/(SICI)1522-2594(200005)43:5<739::AID-MRM17>3.0.CO;2-2
KA Hansen SV David JL Gallant (2004) ArticleTitleParametric reverse correlation reveals spatial linearity of retinotopic human V1 BOLD response Neuroimage 23 233–241 Occurrence Handle15325370 Occurrence Handle10.1016/j.neuroimage.2004.05.012
MK Hasnain PT Fox MG Woldorff (1998) ArticleTitleIntersubject variability of functional areas in the human visual cortex Hum Brain Mapp 6 301–315 Occurrence Handle9704267 Occurrence Handle1:STN:280:DyaK1czmvFyqsg%3D%3D Occurrence Handle10.1002/(SICI)1097-0193(1998)6:4<301::AID-HBM8>3.0.CO;2-7
RD Hoge J Atkinson B Gill GR Crelier S Marrett GB Pike (1999) ArticleTitleStimulus-dependent BOLD and perfusion dynamics in human V1 Neuroimage 9 573–585 Occurrence Handle10334901 Occurrence Handle1:STN:280:DyaK1M3ps1OlsA%3D%3D Occurrence Handle10.1006/nimg.1999.0443
S Kemeny FQ Ye R Birn AR Braun (2004) ArticleTitleComparison of continuous overt speech fMRI using BOLD and arterial spin labeling Hum Brain Mapp 24 173–183 Occurrence Handle10.1002/hbm.20078
KK Kwong JW Belliveau DA Chesler IE Goldberg RM Weisskoff BP Poncelet DN Kennedy BE Hoppel MS Cohen R Turner (1992) ArticleTitleDynamic magnetic resonance imaging of human brain activity during primary sensory stimulation Proc Natl Acad Sci USA 89 5675–5679 Occurrence Handle1608978 Occurrence Handle1:STN:280:By2A3c3jtVA%3D Occurrence Handle10.1073/pnas.89.12.5675
S Lai AL Hopkins EM Haacke D Li BA Wasserman P Buckley L Friedman H Meltzer P Hedera R Friedland (1993) ArticleTitleIdentification of vascular structures as a major source of signal contrast in high resolution 2D and 3D functional activation imaging of the motor cortex at 1.5 T: preliminary results Magn Reson Med 30 387–392 Occurrence Handle8412613 Occurrence Handle1:STN:280:ByuD3MflsVM%3D
C Lehmann T Mueller A Federspiel D Hubl G Schroth O Huber W Strik T Dierks (2004) ArticleTitleDissociation between overt and unconscious face processing in fusiform face area Neuroimage 21 75–83 Occurrence Handle14741644 Occurrence Handle10.1016/j.neuroimage.2003.08.038
WM Luh EC Wong PA Bandettini JS Hyde (1999) ArticleTitleQUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling Magn Reson Med 41 1246–1254 Occurrence Handle10371458 Occurrence Handle1:STN:280:DyaK1M3pslylug%3D%3D Occurrence Handle10.1002/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N
JB Mandeville JJ Marota C Ayata G Zaharchuk MA Moskowitz BR Rosen RM Weisskoff (1999) ArticleTitleEvidence of a cerebrovascular postarteriole windkessel with delayed compliance J Cereb Blood Flow Metab 19 679–689 Occurrence Handle10366199 Occurrence Handle1:STN:280:DyaK1M3pt1ehsw%3D%3D Occurrence Handle10.1097/00004647-199906000-00012
KL Miller WM Luh TT Liu A Martinez T Obata EC Wong LR Frank RB Buxton (2001) ArticleTitleNonlinear temporal dynamics of the cerebral blood flow response Hum Brain Mapp 13 1–12 Occurrence Handle11284042 Occurrence Handle1:STN:280:DC%2BD3MzmvFGjug%3D%3D Occurrence Handle10.1002/hbm.1020
T Obata TT Liu KL Miller WM Luh EC Wong LR Frank RB Buxton (2004) ArticleTitleDiscrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients Neuroimage 21 144–153 Occurrence Handle14741651 Occurrence Handle10.1016/j.neuroimage.2003.08.040
S Ogawa RS Menon DW Tank SG Kim H Merkle JM Ellermann K Ugurbil (1993) ArticleTitleFunctional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model Biophys J 64 803–812 Occurrence Handle8386018 Occurrence Handle1:CAS:528:DyaK3sXhvVOjtLc%3D Occurrence Handle10.1016/S0006-3495(93)81441-3
RC Oldfield (1971) ArticleTitleThe assessment and analysis of handedness: the Edinburgh inventory Neuropsychologia 9 97–113 Occurrence Handle5146491 Occurrence Handle1:STN:280:CS2C28vgvFc%3D Occurrence Handle10.1016/0028-3932(71)90067-4
DA Roberts JA Detre L Bolinger EK Insko JS Leigh SuffixJr (1994) ArticleTitleQuantitative magnetic resonance imaging of human brain perfusion at 1.5 T using steady-state inversion of arterial water Proc Natl Acad Sci USA 91 33–37 Occurrence Handle8278387 Occurrence Handle1:CAS:528:DyaK2cXhtVSktLc%3D Occurrence Handle10.1073/pnas.91.1.33
SA Rombouts F Barkhof FG Hoogenraad M Sprenger P Scheltens (1998) ArticleTitleWithin-subject reproducibility of visual activation patterns with functional magnetic resonance imaging using multislice echo planar imaging Magn Reson Imaging 16 105–113 Occurrence Handle9508267 Occurrence Handle1:STN:280:DyaK1c7mslKqsA%3D%3D Occurrence Handle10.1016/S0730-725X(97)00253-1
AC Silva SP Lee C Iadecola SG Kim (2000) ArticleTitleEarly temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation J Cereb Blood Flow Metab 20 201–206 Occurrence Handle10616809 Occurrence Handle1:CAS:528:DC%2BD3cXhtFSjsLo%3D Occurrence Handle10.1097/00004647-200001000-00025
AC Silva SP Lee G Yang C Iadecola SG Kim (1999) ArticleTitleSimultaneous blood oxygenation level-dependent and cerebral blood flow functional magnetic resonance imaging during forepaw stimulation in the rat J Cereb Blood Flow Metab 19 871–879 Occurrence Handle10458594 Occurrence Handle1:STN:280:DyaK1MzosFOktA%3D%3D Occurrence Handle10.1097/00004647-199908000-00006
SL Talagala FQ Ye PJ Ledden S Chesnick (2004) ArticleTitleWhole-brain 3D perfusion MRI at 3.0 T using CASL with a separate labeling coil Magn Reson Med 52 131–140 Occurrence Handle15236376 Occurrence Handle10.1002/mrm.20124
J Talairach P Tournoux (1988) Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging Thieme Stuttgart New York
J Wang GK Aguirre DY Kimberg JA Detre (2003a) ArticleTitleEmpirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 T Neuroimage 19 1449–1462 Occurrence Handle10.1016/S1053-8119(03)00255-6
J Wang GK Aguirre DY Kimberg AC Roc L Li JA Detre (2003b) ArticleTitleArterial spin labeling perfusion fMRI with very low task frequency Magn Reson Med 49 796–802 Occurrence Handle10.1002/mrm.10437
J Wang DJ Licht GH Jahng CS Liu JT Rubin J Haselgrove RA Zimmerman JA Detre (2003c) ArticleTitlePediatric perfusion imaging using pulsed arterial spin labeling J Magn Reson Imaging 18 404–413 Occurrence Handle10.1002/jmri.10372
J Wang Z Wang GK Aguirre JA Detre (2005) ArticleTitleTo smooth or not to smooth? ROC analysis of perfusion fMRI data Magn Reson Imaging 23 75–81 Occurrence Handle15733791 Occurrence Handle1:CAS:528:DC%2BD2MXjt1yntrc%3D Occurrence Handle10.1016/j.mri.2004.11.009
EC Wong RB Buxton LR Frank (1997) ArticleTitleImplementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling NMR Biomed 10 237–249 Occurrence Handle9430354 Occurrence Handle1:STN:280:DyaK1c%2FptVaiuw%3D%3D Occurrence Handle10.1002/(SICI)1099-1492(199706/08)10:4/5<237::AID-NBM475>3.0.CO;2-X
EC Wong RB Buxton LR Frank (1998) ArticleTitleQuantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II) Magn Reson Med 39 702–708 Occurrence Handle9581600 Occurrence Handle1:STN:280:DyaK1c3ktVKktA%3D%3D
EC Wong RB Buxton LR Frank (1999) ArticleTitleQuantitative perfusion imaging using arterial spin labeling Neuroimaging Clin North Am 9 333–342 Occurrence Handle1:STN:280:DyaK1M3lt1aquw%3D%3D
Y Yang W Engelien H Pan S Xu DA Silbersweig E Stern (2000) ArticleTitleA CBF-based event-related brain activation paradigm: characterization of impulse-response function and comparison to BOLD Neuroimage 12 287–297 Occurrence Handle10944411 Occurrence Handle1:STN:280:DC%2BD3cvotFKisA%3D%3D Occurrence Handle10.1006/nimg.2000.0625
Y Yang H Gu EA Stein (2004) ArticleTitleSimultaneous MRI acquisition of blood volume, blood flow, and blood oxygenation information during brain activation Magn Reson Med 52 1407–1417 Occurrence Handle15562477 Occurrence Handle10.1002/mrm.20302
XH Zhu SG Kim P Andersen S Ogawa K Ugurbil W Chen (1998) ArticleTitleSimultaneous oxygenation and perfusion imaging study of functional activity in primary visual cortex at different visual stimulation frequency: quantitative correlation between BOLD and CBF changes Magn Reson Med 40 703–711 Occurrence Handle9797153 Occurrence Handle1:STN:280:DyaK1M%2FhtFWktQ%3D%3D
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Federspiel, A., Müller, T., Horn, H. et al. Comparison of spatial and temporal pattern for fMRI obtained with BOLD and arterial spin labeling. J Neural Transm 113, 1403–1415 (2006). https://doi.org/10.1007/s00702-006-0434-5
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DOI: https://doi.org/10.1007/s00702-006-0434-5