Skip to main content

Advertisement

SpringerLink
Log in

Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = −0.57, p < 0.002) and with the DBP levels (r = −0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • RM Anthenelli RA Maxwell (2000) ArticleTitleCigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls Alcohol Clin Exp Res 24 987–995 Occurrence Handle10924001 Occurrence Handle1:CAS:528:DC%2BD3cXlslegurs%3D Occurrence Handle10.1111/j.1530-0277.2000.tb04641.x

    Article  PubMed  CAS  Google Scholar 

  • J Balldin U Berggren J Engel M Eriksson (1994a) ArticleTitleNeuroendocrine evidence for reduced serotonergic neurotransmission during heavy drinking Alcohol Clin Exp Res 18 822–825 Occurrence Handle1:STN:280:ByqD28fnsVY%3D Occurrence Handle10.1111/j.1530-0277.1994.tb00045.x

    Article  CAS  Google Scholar 

  • J Balldin U Berggren J Engel M Eriksson E Hård B Söderpalm (1994b) ArticleTitleEffect of citalopram on alcohol intake in heavy drinkers Alcohol Clin Exp Res 18 1133–1136 Occurrence Handle1:STN:280:ByqC2M%2FisF0%3D Occurrence Handle10.1111/j.1530-0277.1994.tb00093.x

    Article  CAS  Google Scholar 

  • JC Ballenger FK Goodwin LF Major GL Brown (1979) ArticleTitleAlcohol and central serotonin metabolism in man Arch Gen Psychiatry 36 224–227 Occurrence Handle420544 Occurrence Handle1:STN:280:CSaC38zitVc%3D

    PubMed  CAS  Google Scholar 

  • CM Banki (1981) ArticleTitleFactors influencing monoamine metabolites and tryptophan in patients with alcohol dependence J Neural Transm 50 89–101 Occurrence Handle6165805 Occurrence Handle1:STN:280:Bi6B3MjktF0%3D Occurrence Handle10.1007/BF01249132

    Article  PubMed  CAS  Google Scholar 

  • LJ Beilin (1995) ArticleTitleAlcohol and hypertension Clin Exp Pharmacol Physiol 22 185–188 Occurrence Handle7554411 Occurrence Handle1:CAS:528:DyaK2MXlsV2qsL4%3D

    PubMed  CAS  Google Scholar 

  • U Berggren M Eriksson C Fahlke J Balldin (2002) ArticleTitleIs long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission Drug Alcohol Depend 65 159–165 Occurrence Handle11772477 Occurrence Handle1:CAS:528:DC%2BD38XitVOr Occurrence Handle10.1016/S0376-8716(01)00154-5

    Article  PubMed  CAS  Google Scholar 

  • U Berggren C Fahlke M Eriksson J Balldin (2003) ArticleTitleTobacco use is associated with reduced central serotonergic neurotransmission in type 1 alcohol-dependent individuals Alcohol Clin Exp Res 27 1257–1261 Occurrence Handle12966319 Occurrence Handle10.1097/01.ALC.0000081627.24693.87

    Article  PubMed  Google Scholar 

  • S Borg H Kvande P Liljeberg D Mossberg P Valverius (1985) ArticleTitleThe 5-hydroxyindoleatic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions Alcohol 2 415–418 Occurrence Handle2411275 Occurrence Handle1:STN:280:BiqB2sbosVE%3D Occurrence Handle10.1016/0741-8329(85)90106-5

    Article  PubMed  CAS  Google Scholar 

  • L Buydens-Branchey M Branchey P Fergeson J Hudson C McKernin (1997) ArticleTitleHormonal, psychological and alcohol craving changes after m-chlorophenylpiperazine administration in alcoholics Alcohol Clin Exp Res 21 220–227 Occurrence Handle9113256 Occurrence Handle1:CAS:528:DyaK2sXjt1eis7g%3D Occurrence Handle10.1111/j.1530-0277.1997.tb03753.x

    Article  PubMed  CAS  Google Scholar 

  • CK Farren D Ziedonis AW Clare FA Hammeedi TG Dinan (1995) ArticleTitleD-fenfluramine-induced prolactin responses in postwithdrawal alcoholics and controls Alcohol Clin Exp Res 19 1578–1592 Occurrence Handle8749830 Occurrence Handle1:CAS:528:DyaK28XhtVyhsb8%3D Occurrence Handle10.1111/j.1530-0277.1995.tb01027.x

    Article  PubMed  CAS  Google Scholar 

  • S Garattini T Mennini R Samanin (1987) ArticleTitleFrom fenfluramine racemate to d-fenfluramine: specificity and potency of the effects on the serotoninergic system and food intake Ann NY Acad Sci 499 156–166 Occurrence Handle2440376 Occurrence Handle1:STN:280:BiiB28bitVA%3D

    PubMed  CAS  Google Scholar 

  • MC Harter KP Conway KR Merikangas (2003) ArticleTitleAssociation between anxiety disorders and physical illness Eur Arch Psychiatry Clin Neurosci 253 313–320 Occurrence Handle14714121 Occurrence Handle10.1007/s00406-003-0449-y

    Article  PubMed  Google Scholar 

  • A Heinz DW Jones C Mazzanti D Goldman P Ragan D Hommer M Linnoila DR Weinberger (2000) ArticleTitleA relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity Biol Psychiatry 47 643–649 Occurrence Handle10745057 Occurrence Handle1:CAS:528:DC%2BD3cXitVSku7Y%3D Occurrence Handle10.1016/S0006-3223(99)00171-7

    Article  PubMed  CAS  Google Scholar 

  • R Invernizzi C Berettera S Garattini R Samanin (1986) ArticleTitleD- and L-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat Eur J Pharmacol 20 9–15 Occurrence Handle10.1016/0014-2999(86)90633-3

    Article  Google Scholar 

  • R Invernizzi R Bertorelli S Consolo S Garattini R Samanin (1989) ArticleTitleEffects of the l-isomer of fenfluramine on dopamine mechanisms in rat brain: further studies Eur J Pharmacol 164 241–248 Occurrence Handle2759175 Occurrence Handle1:CAS:528:DyaL1MXktlemu7k%3D Occurrence Handle10.1016/0014-2999(89)90464-0

    Article  PubMed  CAS  Google Scholar 

  • S Kumar RK Singh U Goswani U Khastgir (2005) ArticleTitleA study of the temporal course of phenomenology of alcohol dependence Am J Addict 14 213–222 Occurrence Handle16019972 Occurrence Handle10.1080/10550490590949550

    Article  PubMed  Google Scholar 

  • MA Lee HY Meltzer (1991) ArticleTitleNeuroendocrine responses to serotonergic agents in alcoholics Biol Psychiatry 30 1017–1030 Occurrence Handle1756196 Occurrence Handle1:CAS:528:DyaK38Xltlequg%3D%3D Occurrence Handle10.1016/0006-3223(91)90122-3

    Article  PubMed  CAS  Google Scholar 

  • PM Miller RF Anton BM Egan J Basile SA Nguyen (2005) ArticleTitleExcessive alcohol consumption and hypertension: clinical implications of current research J Clin Hypertens 7 346–351

    Google Scholar 

  • MF Muldoon R Mackey KV Williams MT Korytkowski JD Flory SB Manuck (2004) ArticleTitleLow central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity J Clin Endocrinol 89 266–271 Occurrence Handle1:CAS:528:DC%2BD2cXmvFCjug%3D%3D Occurrence Handle10.1210/jc.2003-031295

    Article  CAS  Google Scholar 

  • MF Muldoon AF Sved JD Flory JM Perel KA Matthews SB Manuck (1998) ArticleTitleInverse relationship between fenfluramine-induced prolactin release and blood pressure in humans Hypertension 32 972–975 Occurrence Handle9856959 Occurrence Handle1:CAS:528:DyaK1MXitVWjsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • IH Page (1954) ArticleTitleSerotonin (5-hydroxytryptamine) Physiol Rev 34 563–588 Occurrence Handle13185755 Occurrence Handle1:CAS:528:DyaG2cXntlSmug%3D%3D

    PubMed  CAS  Google Scholar 

  • R Ramasubbu (2003) ArticleTitleSerotonin transporter gene functional polymorphism: a plaus candidate gene for increased vascular risk in depression Med Hypotheses 59 537–551 Occurrence Handle10.1016/S0306-9877(02)00244-X

    Article  Google Scholar 

  • C Reist C Mazzanti R Vu D Tran D Goldman (2001) ArticleTitleSerotonin transporter polymorphism is associated with attenuated prolactin response Am J Med Genet (Neuropsyciatr Genet) 105 363–368 Occurrence Handle1:STN:280:DC%2BD3M3pslSitw%3D%3D Occurrence Handle10.1002/ajmg.1360

    Article  CAS  Google Scholar 

  • R Rothman M Bauman (2002) ArticleTitleSerotonin releasing agents. Neurochemical, therapeutic and adverse effects Pharm Biochem Behav 71 825–836 Occurrence Handle1:CAS:528:DC%2BD38XhvVChu7Y%3D Occurrence Handle10.1016/S0091-3057(01)00669-4

    Article  CAS  Google Scholar 

  • JB Saunders DG Beevers A Paton (1981) ArticleTitleAlcohol-induced hypertension Lancet ii 653–656 Occurrence Handle10.1016/S0140-6736(81)90995-8

    Article  Google Scholar 

  • N Singewald L Juen Gou C Schneider S Kaehler A Philippu (1995) ArticleTitleSerotonin outflow in the hypothalamus of conscious rats: original and possible involvement in cardiovascular control Eur J Pharmacol 294 787–793 Occurrence Handle8750746 Occurrence Handle1:CAS:528:DyaK28XntFKh Occurrence Handle10.1016/0014-2999(95)00652-4

    Article  PubMed  CAS  Google Scholar 

  • SD Stocker MF Muldoon AF Sved (2003) ArticleTitleBlunted fenfluramine-evoked prolactin secretion in hypertensive rats Hypertension 42 719–724 Occurrence Handle12885788 Occurrence Handle1:CAS:528:DC%2BD3sXosF2rtrY%3D Occurrence Handle10.1161/01.HYP.0000082807.71659.4C

    Article  PubMed  CAS  Google Scholar 

  • H-G Weijers GA Wiesbeck F Jakob J Böning (2001) ArticleTitleNeuroendocrine responses to fenfluramine and its relationship to personality in alcoholism J Neural Transm 108 1093–1105 Occurrence Handle11716144 Occurrence Handle1:CAS:528:DC%2BD3MXotlGjsL0%3D Occurrence Handle10.1007/s007020170027

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital/Mölndal, Göteborg, Sweden

    J. Balldin, M. Andersson, U. Berggren & M. Eriksson

  2. Psychiatric Clinic Kungälv Hospital, Göteborg, Sweden

    U. Berggren

  3. Department of Pharmacology, Institute of Physiology and Pharmacology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

    J. Engel

  4. Department of Psychology, Göteborg University, Göteborg, Sweden

    C. Fahlke

Authors
  1. J. Balldin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Andersson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Berggren
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Engel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Eriksson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Fahlke
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Balldin, J., Andersson, M., Berggren, U. et al. Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects. J Neural Transm 113, 1511–1517 (2006). https://doi.org/10.1007/s00702-005-0426-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-005-0426-x

Search

Navigation