Abstract
Regression of meningioma after haemorrhage and the cessation of hormone treatment is well reported. However, spontaneous regression is very rarely observed. Here, we report the spontaneous regression of a parafalcine meningioma in a 56-year-old woman with multiple sclerosis, who was referred to our department after an incidental finding on magnetic resonance imaging. She was being treated with interferon beta-1a to manage the symptoms. To our knowledge, this is the first report of spontaneous regression of meningioma in a patient receiving interferon beta-1a therapy and just the second report of spontaneous regression in general.
Similar content being viewed by others
References
Batay F, Al-Merfy O (2002) Growth dynamics of meningiomas in patients with multiple sclerosis treated with interferon: report in two cases. Acta Neurochir (Wein) 144:365–368
Cea-Soriano L, Wallander M, García RL (2012) Epidemiology of Meningioma in the United Kingdom. Neuroepidemiology 39(1):27–34
Ricci SB, Cerchiari U (2010) Spontaneous regression of malignant tumors: importance of the immune system and other factors (Review). Oncol Lett 1(6)941-945
de Almeida J, Petteys R, Sciubba D, Gallia G, Brem H (2009) Regression of intracranial meningioma following intratumoral haemorrhage. J Clin Neurosci 16(9):1246–1249
Dekkers OM, Pereira AM, Romijn JA (2008) Treatment and follow-up of clinically nonfunctioning pituitary macroadenomas. J Clin Endocrinol Metab 93:3717–26
Drevelegas A, Xinou E, Karacostas D, Parissis D, Karlavelas G, Milonas I (2005) Meningioma growth and interferon beta-1B treated multiple sclerosis: coincidence or relationship? Neuroradiology 47(7):516–519
Gama H, Rocha A, Silva C, Mendes M, Veiga J, Lancellotti C, Andrade V, Tilbery C (2008) Meningioma growth during interferon beta-1A treatment for multiple sclerosis. Arq Neuro-Psiquiatr 66(2):402–404
Goncalves A, Page P, Domigo V, Meder J, Oppenheim C (2010) Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol 31(8):1504–1505
Hashiba T, Hashimoto N, Izumoto S, Suzuki T, Kagawa N, Maruno M, Kato A, Yoshimine T (2009) Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas. J Neurosurg 110(4):675–684
Huang X, Caye-Thomasen P, Stangerup S (2013) Spontaneous tumour shrinkage in 1261 observed patients with sporadic vestibular schwannoma. J Laryngol Otol 127:739–743
Janiszewska A, Poletajew S, Wasiutyński A (2013) Reviews Spontaneous regression of renal cell carcinoma. Contemp Oncol 2:123–127
Kaba S, De Monte F, Bruner J, Kyritsis A, Jaekle K, Levin V, Yung A (1997) The treatment of recurrent unresectable and malignant meningiomas with interferon alpha-2b. Neurosurgery 40(2):271–275
Kasuya H, Akagawa H, Fujita T, Hirota K, Onda H (2014) Spontaneous regression together with increased calcification of incidental meningioma. Surg Neurol Int 5(1):73
Liu A, Wang J, Li G, Sun Y, Sun S, Luo B, Wang M (2014) Clinical and pathological analysis of benign brain tumors resected after gamma knife surgery. J Neurosurg 121:179–187
Moller H, Kneller R, Boice J, Olsen J (1991) Cancer incidence following hospitalization for multiple sclerosis in Denmark. Acta Neurol Scand 84:214–220
Stewart F (1952) Experiences in spontaneous regression of neoplastic disease in man. Texas Rep Biol Med 10:239–253
Vieira R, Vale T, Rocha C, Araújo C, Lana-Peixoto M (2012) Meningioma after immunomodulation for multiple sclerosis. Arq Neuro-Psiquiatr 70(1):75–76
Weinstock B, Ramanathan M, Zivadinov R (2008) Interferon-beta treatment for relapsing multiple sclerosis. Expert Opin Biol Ther 8(9):1435–1447
Acknowledgements
The patient has consented to submission of this case report to the journal. No patient-identifying material has been included.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflicts of interest.
Additional information
An erratum to this article is available at http://dx.doi.org/10.1007/s00701-016-3048-1.
Rights and permissions
About this article
Cite this article
Galloway, L., Vakili, N. & Spears, J. Spontaneous regression of a parafalcine meningioma in a multiple sclerosis patient being treated with interferon beta-1a. Acta Neurochir 159, 469–471 (2017). https://doi.org/10.1007/s00701-016-3019-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-016-3019-6