Abstract
Clinical case
We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings.
Conclusion
This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.
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Funding
This research was supported by the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED.
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After written informed consent was obtained from her parents, bevacizumab was commenced at 10 mg/kg.
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On behalf of all authors, the corresponding author states that there is no conflict of interest.
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Miyata, K., Hori, T., Shimomura, Y. et al. Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma. Childs Nerv Syst 34, 2305–2308 (2018). https://doi.org/10.1007/s00381-018-3841-7
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DOI: https://doi.org/10.1007/s00381-018-3841-7