Abstract
Eosinophilic granuloma (EG) is a rare benign osteolytic lesion observed rarely in adults, with only some 18 cases of spinal location reported in the literature. We present an unusual variant of EG in a 23-year-old man with radiological features of multiple spinal lytic lesions which was evocated of metastatic processes. A surgically transpedicular biopsy of the thoracic collapsed vertebrae with posterior stabilization was made. Histological examination of the tissue showed features of eosinophilic granuloma. The clinical and radiological findings of EG present dilemmas of both diagnosis and treatment. The etiology is unclear and the therapeutic approach is still controversial.
Similar content being viewed by others
References
Acciarri N, Paganini M, Fonda C, Gaist G, Padovani R (1992) Langerhans cell histiocytosis of the spine causing cord compression: case report. Neurosurgery 31(5):965–968. doi:10.1097/00006123-199211000-00025
Bertram C, Madert J, Eggers C (2002) Eosinophilic granuloma of the cervical spine. Spine 27(13):1408–1413. doi:10.1097/00007632-200207010-00007
Garg B, Sharma V, Eachempati KK, Malhotra R, Bhan S (2006) An unusual presentation of eosinophilic granuloma in an adult: a case report. J Orthop Surg (Hong Kong) 14(1):81–83
Garg S, Mehta S, Dormans JP (2004) Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am 86:1740–1750
Islinger RB, Kuklo TR, Owens BD, Horan PJ, Choma TJ, Murphey MD, Temple HT (2000) Langerhans’ cell histiocytosis in patients older than 21 years. Clin Orthop Relat Res 379:231–235. doi:10.1097/00003086-200010000-00027
Raab P, Hohmann F, Kühl J, Krauspe R (1998) Vertebral remodeling in eosinophilic granuloma of the spine: a long-term follow-up. Spine 23(12):1351–1354. doi:10.1097/00007632-199806150-00011 Case report
Reddy PK, Vannemreddy PS, Nanda A (2000) Eosinophilic granuloma of spine in adults: a case report and review of literature. Spinal Cord 38:766–768. doi:10.1038/sj.sc.3101061
Yasko AW, Fanning CV, Ayala AG, Carrasco CH, Murray JA (1998) Percutaneous techniques for the diagnosis and treatment of localized Langerhans-cell histiocytosis (eosinophilic granuloma of bone). J Bone Joint Surg Am 80:219–228
Yeom JS, Lee CK, Shin HY, Lee CS, Han CS, Chang H (1999) Langerhans’ cell histiocytosis of the spine analysis of twenty-three cases. Spine 24:1740–1749. doi:10.1097/00007632-199908150-00016
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
El Asri, A.C., Akhaddar, A., El Mostarchid, B. et al. Multiple lytic lesions of the spine: a rare diagnosis of eosinophilic granuloma in an adult: a case report. Acta Neurochir 152, 703–706 (2010). https://doi.org/10.1007/s00701-009-0434-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00701-009-0434-y