Abstract.
Phenytoin sodium reacts with o-nitrobenzoic acid in alkaline media after heating for 10 minutes at 70 °C, to give a red coloured complex having maximum absorbance at 510 nm. The reaction is selective for phenytoin sodium with 0.01 mg/10 mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.01 mg to 3 mg/10 mL of phenytoin sodium and the relative standard deviation is 0.29%. The quantitative assessment of tolerable amounts of other drugs is also studied.
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Received May 2, 2000. Revision May 11, 2001.
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Aman, T., Firdous, S., Khan, I. et al. Spectrophotometric Determination of Phenytoin Sodium in Pure and Pharmaceutical Preparations. Mikrochim Acta 137, 121–126 (2001). https://doi.org/10.1007/s006040170001
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DOI: https://doi.org/10.1007/s006040170001