Abstract
A photoelectrochemical sensor for target detection of hydrogen peroxide was designed based on a new heterojunction nanocomposite which was sulfhydryl-borate ester–modified A1/B1-type pillar[5]arene (BP5)–functionalized Au NPs and multi-walled carbon nanotubes hybridized with bismuth bromide oxide (Au@BP5/MWNTs-BiOBr). The specific sensor was based on the direct induction of oxidation by hydrogen peroxide of the borate ester group of pillar[5]arene. Additionally, the local surface plasmon resonance (LSPR) of Au NPs enhanced visible light capture, the host–guest complexation of BP5 with H2O2 enhanced photocurrent response, the layer-by-layer stacked nanoflower structure of BiOBr provided large specific surface area with more active sites, and the conductivity of MWNTs enhanced the charge separation efficiency and significantly improves the stability of PEC. Their synthesis effect significantly increased the photocurrent signal and further enhanced the detection result. Under the optimal conditions, the linear concentration range of H2O2 detected by the Au@BP5/MWNTs-BiOBr sensor was from 1 to 60 pmol/L. The limit of detection (LOD) and the limit of quantification (LOQ) of the method were 0.333 pmol/L and 1 pmol/L, respectively, and the sensitivity was 6.471 pmol/L. Importantly, the PEC sensor has good stability, reproducibility, and interference resistance and can be used for the detection of hydrogen peroxide in real cells.
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References
Jacewicz D, Siedleck-kroplewska K, Drzeżdżon J et al (2017) Method for detection of hydrogen peroxide in HT22 cells. J Sci Rep 7:45673
Jiao X, Li Y, Niu J et al (2017) Small-molecule fluorescent probes for imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems. J Anal Chem 90:533–555
Asif M, Aziz A, Ashraf G et al (2022) Unveiling microbiologically influenced corrosion engineering to transfigure damages into benefits: a textile sensor for H2O2 detection in clinical cancer tissues. J Chem Eng J 427:131398
Weidinger A, Kozlov A (2015) Biological activities of reactive oxygen and nitrogen species: oxidative stress versus signal transduction. J Biomol 5:472–484
Asif M, Haitao W, Shuang D et al (2017) Metal oxide intercalated layered double hydroxide nanosphere: with enhanced electrocatalyic activity towards H2O2 for biological applications. J Sensors Actuators B: Chem 239:243–252
Lampard EV, Sedgwick AC, Sun X et al (2018) Boronate-based fluorescence probes for the detection of hydrogen peroxide. J Chemistryopen 7:262–265
Asif M, Liu H, Aziz A et al (2017) Core-shell iron oxide-layered double hydroxide: high electrochemical sensing performance of H2O2 biomarker in live cancer cells with plasma therapeutics. J Biosens Bioelectron 97:352–359
Zhang Z, Liu H, Zhai L et al (2023) Construction of BiOCl-TNTs photoelectrochemical sensor for detection of hydrogen peroxide. J Chem Phys Lett 811:140177
Cheng D, Wu H, Feng C et al (2022) Bifunctional photoelectrochemical sensor based on Bi/Bi2S3/BiVO4 for detecting hexavalent chromium and hydrogen peroxide. J Sensors Actuators B: Chem 353:131108
Zhang M, Chen M, Liu Y et al (2019) Catalase-inorganic hybrid microflowers modified glassy carbon electrode for amperometric detection of hydrogen peroxide. J Mater Lett 243:9–12
Dutta A, Maitra U (2022) Naked-eye detection of hydrogen peroxide on photoluminescent paper discs. J Am Chem Soc 7:512–522
Wei Y, Liu Y, He Y et al (2021) Mitochondria and lysosome-targetable fluorescent probes for hydrogen peroxide. J J Mater Chem B 9:908–920
Zou J, Cai H, Wang D et al (2019) Spectrophotometric determination of trace hydrogen peroxide via the oxidative coloration of DPD using a Fenton system. J Chemosphere 224:646–652
Li Z, Lu J, Wei W et al (2022) Recent advances in electron manipulation of nanomaterials for photoelectrochemical biosensors. J Chem Commun 58:12418–12430
Li F, Zhou Y, Yin H et al (2022) Recent advances on signal amplification strategies in photoelectrochemical sensing of microRNAs. J Biosens Bioelectron 166:112476
Wang S, Kuang P, Cheng B et al (2018) ZnO hierarchical microsphere for enhanced photocatalytic activity. J J Alloys Compd 741:622–632
Zang J, Cheng F, Li J et al (2016) Fluorescent nanoprobes for sensing and imaging of metal ions: recent advances and future perspectives. J Nano Today 11:309–329
Zhang L, Ying Y, Li Y et al (2020) Integration and synergy in protein-nanomaterial hybrids for biosensing: strategies and in-field detection applications. J Biosens Bioelectron 154:112036
Ai Y, Liang P, Wu Y et al (2018) Rapid qualitative and quantitative determination of food colorants by both Raman spectra and surface-enhanced Raman scattering (SERS). J Food Chem 241:427–433
Pancholi D, Bisht NS, Pande V et al (2021) Development of novel BiOBr0.75I0.25 nanostructures with remarkably high dark phase bactericidal activities. J Colloids and Surfaces B: Biointerfaces 199:111558
Guo Y, Wang P, Qian J et al (2017) Construction of a composite photocatalyst with significantly enhanced photocatalytic performance through combination of homo-junction with hetero-junction. J Catal Sci Technol 8:486–498
Zhang W, Dong F, Xiong T et al (2014) Synthesis of BiOBr–graphene and BiOBr–graphene oxide nanocomposites with enhanced visible light photocatalytic performance. J Ceram Int 40:9003–9008
Janani S, Sudha Rani KS, Ellappan P et al (2016) Photodegradation of methylene blue using magnetically reduced graphene oxide bismuth oxybromide composite. J J Environ Chem Eng 4:534–541
Bisht NS, Tripathi AH, Pant M et al (2022) A facile synthesis of palladium nanoparticles decorated bismuth oxybromide nanostructures with exceptional photo-antimicrobial activities. J Colloids Surf B: Biointerfaces 217:112640
Asif M, Aziz A, Wang H et al (2019) Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid. J Microchim Acta 186:61
Monti S, Barcaro G, Goddard WA III et al (2021) Diverse phases of carbonaceous materials from stochastic simulations. J ACS Nano 15:6369–6385
Asif M, Aziz A, Wang Z et al (2019) Hierarchical CNTs@CuMn layered double hydroxide nanohybrid with enhanced electrochemical performance in H2S detection from live cells. J Anal Chem 91:3912–3920
Zhang B, He Y, Liu B et al (2014) NiCoBP-doped carbon nanotube hybrid: a novel oxidase mimetic system for highly efficient electrochemical immunoassay. J Anal Chim Acta 851:49–56
Lee H, Yoon SW, Kim EJ et al (2007) In-situ growth of copper sulfide nanocrystals on multiwalled carbon nanotubes and their application as novel solar cell and amperometric glucose sensor materials. J Nano Lett 7:778–784
Lin Y, Chen X, Lin Y et al (2015) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite made from carbon nanotubes and molybdenum disulfide. J Microchim Acta 182:1803–1809
Chen Y, Sun S, Lu D et al (2019) Water-soluble supramolecular polymers constructed by macrocycle-based host-guest interactions. J Chin Chem Lett 30:37–43
Jiang C, Song Z, Yu L et al (2020) Fluorescent probes based on macrocyclic hosts: construction, mechanism and analytical applications. J TrAC Trends Anal Chem 133:116086
Guo F, Sun Y, Xi B et al (2017) Recent progress in the research on the host-guest chemistry of pillar[n]arenes. J Supramol Chem 30:1–12
Guo L, Du J, Wang Y et al (2020) Advances in diversified application of pillar[n]arenes. J J Incl Phenom Macrocycl Chem 97:1–17
Yuan Z, Hu CC, Chang HT et al (2016) Gold nanoparticles as sensitive optical probes. J Anal 144:1611–1626
Cai G, Yu Z, Ren R et al (2018) Exciton–plasmon interaction between AuNPs/graphene nanohybrids and CdS quantum Dots/TiO2 for photoelectrochemical aptasensing of prostate-specific antigen. J ACS Sensors 3:632–639
Lv S, Zang K, Zhou Q et al (2020) Plasmonic enhanced photoelectrochemical aptasensor with D-A F8BT/g-C3N4 heterojunction and AuNPs on a 3D-printed device. J Sensors Actuators B: Chem 310:127874
Zhou Q, Albert O, Deng H et al (2012) Effect of functional groups on the crystallization of ferric oxides/oxyhydroxides in suspension environment. J Front Mater Sci 6:297–303
Asif M, Aziz A, Ashraf G et al (2018) Facet-inspired core–shell gold nanoislands on metal oxide octadecahedral heterostructures: high sensing performance toward sulfide in biotic fluids. J ACS Appl Mater Interfaces 10:36675–36685
Liu F, Dai Y, Chen F et al (2020) Lead bismuth oxybromide/graphene oxide: synthesis, characterization, and photocatalytic activity for removal of carbon dioxide, crystal violet dye, and 2-hydroxybenzoic acid. J J Colloid Interface Sci 562:112–124
Wang J, Zhou L, Bei J et al (2022) An enhanced photo-electrochemical sensor constructed from pillar [5]arene functionalized Au NPs for ultrasensitive detection of caffeic acid. J Talanta 243:123322
Wang J, Zhou L, Bei J et al (2022) An specific photoelectrochemical sensor based on pillar[5]arenes functionalized gold nanoparticles and bismuth oxybromide nanoflowers for bovine hemoglobin recognition. J J Colloid Interface Sci 620:187–198
Wang J, Bei J, Guo X et al (2022) Ultrasensitive photoelectrochemical immunosensor for carcinoembryonic antigen detection based on pillar[5]arene-functionalized Au nanoparticles and hollow PANI hybrid BiOBr heterojunction. J Biosens Bioelectron 208:114220
Tharmaraj V, Anbu, Anjugam, Vandarkuzhali S, Karthiletan G, et al (2022) Efficient and recyclable AuNPs/aminoclay nanocomposite catalyst for the reduction of organic dyes. J Surfaces and Interfaces 32:102052
Gao Y, Yu Z, Huang L et al (2023) Photoinduced electron transfer modulated photoelectric signal: toward an organic small molecule-based photoelectrochemical platform for formaldehyde detection [J]. Anal Chem 95:9130–9137
Lu L, Zeng R, Lin Q et al (2023) Cation exchange reaction-mediated photothermal and polarity-switchable photoelectrochemical dual-readout biosensor. J Anal Chem 95:16335–16342
Wang J, Lu C, Chen T et al (2019) Simply synthesized nitrogen-doped graphene quantum dot (NGQD)-modified electrode for the ultrasensitive photoelectrochemical detection of dopamine. J Nanophotonics 9:3831–3839
Jiang J, Zhang X, Sun P et al (2011) ZnO/BiOI heterostructures: photoinduced charge-transfer property and enhanced visible-light photocatalytic activity. J J Phys Chem C 115:20555–20564
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This work was supported by the National Natural Science Foundation of China (grant no. 32101215).
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Wang, J., Zhou, Q., Fan, C. et al. Ultrasensitive and specific photoelectrochemical sensor for hydrogen peroxide detection based on pillar[5]arene-functionalized Au nanoparticles and MWNTs hybrid BiOBr heterojunction. Microchim Acta 191, 266 (2024). https://doi.org/10.1007/s00604-024-06302-7
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DOI: https://doi.org/10.1007/s00604-024-06302-7