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Photoelectrochemical sensing of isoniazid and streptomycin based on metal Bi-doped BiOI microspheres grown on book-shape layers of Ti3C2 heterostructures

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Abstract

Isoniazid and streptomycin are vital drugs for treating tuberculosis, which are utilized as efficient anti-tuberculosis agents. This paper presents a novel visible-light-driven composite photocatalyst Ti3C2/Bi/BiOI, which was built from Ti3C2 nanosheets and Bi/BiOI microspheres. Photoelectrochemical (PEC) sensors based on Ti3C2/Bi/BiOI were synthesized for isoniazid identification, which showed a linear concentration range of 0.1–125 μM with a detection limit of 0.05 μM (S/N = 3). Moreover, we designed a PEC aptasensors based on aptamer/Ti3C2/Bi/BiOI to detect streptomycin in 0.1 M PBS covering the electron donor isoniazid, because the isoniazid consumes photogenerated holes thus increasing the photocurrent effectively and preventing photogenerated electron–hole pairs from being recombined. Furthermore, PEC aptasensors based on aptamer/Ti3C2/Bi/BiOI were synthesized for streptomycin identification, which exhibited a linear concentration range of 0.01–1000 nM with a detection limit of 2.3 × 10-3 nM (S/N = 3), and are well stable in streptomycin sensing.

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Data available on request from the authors.

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Acknowledgements

This work was supported by Key scientific and technological projects in Henan Province (202102310036).

Author information

Author notes

  1. Chengzhi Ding, Shengnan Ma and Shuohao Wang are co-authors.

Authors and Affiliations

  1. Department of Thoracic Surgery, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, China

    Chengzhi Ding & Li Wei

  2. Department of Thoracic Surgery, Henan Provincial Chest Hospital Affiliated to Zhengzhou University, Zhengzhou, China

    Chengzhi Ding & Yuanyuan Liu

  3. Henan provincial tuberculosis International Joint Laboratory, Henan Provincial Chest Hospital Affiliated to Zhengzhou University, Zhengzhou, China

    Chengzhi Ding, Wei Wang & Huihui Chen

  4. Henan Provincial Key Laboratory of Tuberculosis Diagnostic Medicine, Henan Provincial Chest Hospital Affiliated to Zhengzhou University, Zhengzhou, China

    Chengzhi Ding, Wei Wang & Huihui Chen

  5. Henan Clinical Medical Research Center of Tuberculosis, Henan Provincial Chest Hospital Affiliated to Zhengzhou University, Zhengzhou, China

    Chengzhi Ding, Wei Wang & Huihui Chen

  6. Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Shengnan Ma & Jiao Wang

  7. Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Shengnan Ma & Jiao Wang

  8. Department of Engineering and Computing, Hong Kong Polytechnic University, Hong Kong, China

    Shuohao Wang

  9. Department of Tuberculosis, Henan Provincial Chest Hospital Affiliated to Zhengzhou University, Zhengzhou, China

    Ruixia Liang

  10. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

    Xufeng Guo

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  1. Chengzhi Ding
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Contributions

Chengzhi Ding and Shengnan Ma: investigation, writing-original draft. Shuohao Wang, Huihui Chen and Zhi Li: formal analysis, experiment and editing, funding acquisition. Li Wei, Shengnan Ma and Chengzhi Ding: formal analysis, conceptualization. Xufeng Guo, Jiao Wang and Li Wei: supervision, funding acquisition and statistical assistance.

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Correspondence to Xufeng Guo, Jiao Wang or Li Wei.

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Ding, C., Ma, S., Wang, S. et al. Photoelectrochemical sensing of isoniazid and streptomycin based on metal Bi-doped BiOI microspheres grown on book-shape layers of Ti3C2 heterostructures. Microchim Acta 191, 260 (2024). https://doi.org/10.1007/s00604-024-06280-w

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