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A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin

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Abstract

A molecularly imprinted electrochemical sensor was designed for the selective determination of gatifloxacin (GTX) based on dual functional monomers. Multi-walled carbon nanotube (MWCNT) enhanced the current intensity and zeolitic imidazolate framework 8 (ZIF8) provided a large surface area to produce more imprinted cavities. In the electropolymerization of molecularly imprinted polymer (MIP), p-aminobenzoic acid (p-ABA) and nicotinamide (NA) were used as dual functional monomers, and GTX was the template molecule. Taking [Fe(CN)6]3−/4− as an electrochemical probe, an oxidation peak on the glassy carbon electrode was located at about 0.16 V (vs. saturated calomel electrode). Due to the diverse interactions among p-ABA, NA, and GTX, the MIP-dual sensor exhibited higher specificity towards GTX than MIP-p-ABA and MIP-NA sensors. The sensor had a wide linear range from 1.00 × 10−14 to 1.00 × 10−7 M with a low detection limit of 2.61 × 10−15 M. Satisfactory recovery between 96.5 and 105% with relative standard deviation from 2.4 to 3.7% in real water samples evidenced the potential of the method in antibiotic contaminant determination.

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Acknowledgements

The authors would like to thank the National Natural Science Foundation of China (No. 22274096).

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, Shanghai University, Shanghai, 200444, People’s Republic of China

    Yan Huang, Xuyuan Sun, Jing Yang, Zhiyuan Cao, Rujie Wang, Li Li & Yaping Ding

  2. Shanghai Key Laboratory of High Temperature Superconductors, Shanghai University, Shanghai, 200444, People’s Republic of China

    Yaping Ding

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  1. Yan Huang
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Correspondence to Li Li or Yaping Ding.

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Huang, Y., Sun, X., Yang, J. et al. A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin. Microchim Acta 190, 261 (2023). https://doi.org/10.1007/s00604-023-05839-3

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