Skip to main content
SpringerLink
Log in

Glucose oxidase@zinc-doped zeolitic imidazolate framework-67 as an effective cascade catalyst for one-step chemiluminescence sensing of glucose

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

A chemiluminescence (CL) sensor was constructed for the one-step determination of glucose. Glucose oxidase (GOx) was successfully encapsulated into Zn-doped zeolitic imidazolate framework-67 (Zn–ZIF–67) via a simple one-pot strategy. The as-prepared GOx@Zn–ZIF–67 nanocomposite can trigger cascade reactions of glucose oxidation to generate H2O2 and H2O2-mediated luminol reaction to give an intense CL emission. The sensor responds linearly to glucose in the 20.0–400.0 μmol·L–1 range with a limit of detection (LOD) of 4.7 μmol·L–1. Eleven replicated measurements of 200.0 μmol·L–1 glucose solution gives a relative standard deviation (RSD) of 1.7%. The sensor exhibits good selectivity and stability and was successfully applied to the determination of glucose in real human serum samples.

Graphical abstract

Schematic representation of one-step determination of serum glucose with GOx@Zn–ZIF–67 nanocomposite triggering cascade reactions between luminol and glucose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1.
Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW (2019) Global trends in diabetes complications: a review of current evidence. Diabetologia 62:3–16. https://doi.org/10.1007/s00125-018-4711-2

    Article  PubMed  Google Scholar 

  2. Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14:88–98. https://doi.org/10.1038/nrendo.2017.151

    Article  PubMed  Google Scholar 

  3. Chen CM, Hung LC, Chen YL, Yeh MC (2018) Perspectives of patients with non–insulin–treated type 2 diabetes on self–monitoring of blood glucose: a qualitative study. J Clin Nurs 27:1673–1683. https://doi.org/10.1111/jocn.14227

    Article  PubMed  Google Scholar 

  4. Baird HM, Webb TL, Martin J, Sirois FM (2018) The relationship between a balanced time perspective and self–monitoring of blood glucose among people with type 1 diabetes. Ann Behav Med 53:196–209. https://doi.org/10.1093/abm/kay028

    Article  Google Scholar 

  5. Jia YX, Sun SC, Cui XJ, Wang XH, Yang L (2019) Enzyme–like catalysis of polyoxometalates for chemiluminescence: application in ultrasensitive detection of H2O2 and blood glucose. Talanta 205:120139. https://doi.org/10.1016/j.talanta.2019.120139

    Article  CAS  PubMed  Google Scholar 

  6. Yu JQ, Cao MY, Wang H, Li YX (2019) Novel manganese(II)–based metal–organic gels: synthesis, characterization and application to chemiluminescent sensing of hydrogen peroxide and glucose. Microchim Acta 186:696. https://doi.org/10.1007/s00604-019-3808-8

    Article  CAS  Google Scholar 

  7. Khajvand T, Alijanpour O, Chaichi MJ, Vafaeezadeh M, Hashemi MM (2015) Imidazolium–based ionic liquid derivative/Cu–II complexes as efficient catalysts of the lucigenin chemiluminescence system and its application to H2O2 and glucose detection. Anal Bioanal Chem 407:6217–6136. https://doi.org/10.1007/s00216-015-8795-y

    Article  CAS  Google Scholar 

  8. Lee YS, Lim K, Minteer SD (2021) Cascaded biocatalysis and bioelectrocatalysis: overview and recent advances. Ann Rev Phys Chem 72:467–488. https://doi.org/10.1146/annurev-physchem-090519-050109

    Article  CAS  Google Scholar 

  9. Wei XL, Han PP, You C (2020) Facilitation of cascade biocatalysis by artificial multi–enzyme complexes–a review. Chinese J Chem Eng 28:2799–2809. https://doi.org/10.1016/j.cjche.2020.05.022

    Article  CAS  Google Scholar 

  10. Quin MB, Wallin KK, Zhang G, Schmidt-Dannert C (2017) Spatial organization of multi–enzyme biocatalytic cascades. Org Biomol Chem 15:4260–4271. https://doi.org/10.1039/c7ob00391a

    Article  CAS  PubMed  Google Scholar 

  11. Yong Y, Ouyang PK, Wu JZ, Liu Z (2020) A diffusion–reaction model for one–pot synthesis of chemicals with enzyme cascades. ChemCatChem 12:528–535. https://doi.org/10.1002/cctc.201901161

    Article  CAS  Google Scholar 

  12. France SP, Hepworth LJ, Turner NJ, Flitsch SL (2017) Constructing biocatalytic cascades: in vitro and in vivo approaches to de novo multi–enzyme pathways. ACS Catal 7:710–724. https://doi.org/10.1021/acscatal.6b02979

    Article  CAS  Google Scholar 

  13. Walsh CT, Moore BS (2019) Enzymatic cascade reactions in biosynthesis. Angew Chem Int Edit 58:6846–6879. https://doi.org/10.1002/anie.201807844

    Article  CAS  Google Scholar 

  14. Zhao Y, Huang YC, Zhu H, Zhu QQ, Xia YS (2016) Three–in–one: sensing, self–assembly, and cascade catalysis of cyclodextrin modified gold nanoparticles. J Am Chem Soc 138:16645–16654. https://doi.org/10.1021/jacs.6b07590

    Article  CAS  PubMed  Google Scholar 

  15. Jia F, Narasimhan B, Mallapragada S (2014) Materials–based strategies for multi–enzyme immobilization and co–localization: a review. Biotechnol Bioeng 111:209–222. https://doi.org/10.1002/bit.25136

    Article  CAS  PubMed  Google Scholar 

  16. Hwang ET, Lee S (2019) Multienzymatic cascade reactions via enzyme complex by immobilization. ACS Catal 9:4402–4425. https://doi.org/10.1021/acscatal.8b04921

    Article  CAS  Google Scholar 

  17. Liang JY, Liang K (2020) Multi–enzyme cascade reactions in metal–organic frameworks. Chem Rec 20:1100–1116. https://doi.org/10.1002/tcr.202000067

    Article  CAS  PubMed  Google Scholar 

  18. Xu WQ, Jiao L, Wu Y, Hu LY, Gu WL, Zhu CZ (2021) Metal–organic frameworks enhance biomimetic cascade catalysis for biosensing. Adv Mater 33:2005172. https://doi.org/10.1002/adma.202005172

    Article  CAS  Google Scholar 

  19. Zhao MY, Li Y, Ma XJ, Xia MF, Zhang YD (2019) Adsorption of cholesterol oxidase and entrapment of horseradish peroxidase in metal–organic frameworks for the colorimetric biosensing of cholesterol. Talanta 200:293–299. https://doi.org/10.1016/j.talanta.2019.03.060

    Article  CAS  PubMed  Google Scholar 

  20. Chen WH, Vázquez-González M, Zoabi A, Abu-Reziq R, Willner I (2018) Biocatalytic cascades driven by enzymes encapsulated in metal–organic framework nanoparticles. Nat Catal 1:689–695. https://doi.org/10.1038/s41929-018-0117-2

    Article  CAS  Google Scholar 

  21. Jing WJ, Kong FB, Tian SJ, Yu MC, Li YC, Fan LZ, Li XH (2021) Glucose oxidase decorated fluorescent metal–organic frameworks as biomimetic cascade nanozymes for glucose detection through the inner filter effect. Analyst 146:4188–4194. https://doi.org/10.1039/d1an00847a

    Article  CAS  PubMed  Google Scholar 

  22. Zhu NF, Gu LT, Wang J, Li XS, Liang GX, Zhou JH, Zhang Z (2019) Novel and sensitive chemiluminescence sensors based on 2D–MOF nanosheets for one–step detection of glucose in human urine. J Phys Chem C 123:9388–9393. https://doi.org/10.1021/acs.jpcc.9b00671

    Article  CAS  Google Scholar 

  23. Zhong GH, Liu DX, Zhang JY (2018) The application of ZIF–67 and its derivatives: adsorption, separation, electrochemistry and catalysts. J Mater Chem A 6:1887–1899. https://doi.org/10.1039/c7ta08268a

    Article  CAS  Google Scholar 

  24. Wang SJ, Xu DP, Ma L, Qiu JX, Wang X, Dong QL, Zhang Q, Pan J, Liu Q (2018) Ultrathin ZIF–67 nanosheets as a colorimetric biosensing platform for peroxidase–like catalysis. Anal Bioanal Chem 410:7145–7152. https://doi.org/10.1007/s00216-018-1317-y

    Article  CAS  PubMed  Google Scholar 

  25. Wu HY, Qian XK, Zhu HP, Ma SH, Zhu GS, Long Y (2016) Controlled synthesis of highly stable zeolitic imidazolate framework–67 dodecahedra and their use towards the templated formation of a hollow Co3O4 catalyst for CO oxidation. RSC Adv 6:6915–6920. https://doi.org/10.1039/c5ra18557b

    Article  CAS  Google Scholar 

  26. Qian XK, Ren QB, Wu XF, Sun J, Wu HY, Lei J (2018) Enhanced water stability in Zn–doped zeolitic imidazolate framework–67 (ZIF–67) for CO2 capture applications. ChemistrySelect 3:657–661. https://doi.org/10.1002/slct.201702114

    Article  CAS  Google Scholar 

  27. Amirzehni M, Hassanzadeh J, Vahid B (2020) Surface imprinted CoZn–bimetalic MOFs as selective colorimetric probe: application for detection of dimethoate. Sensor Actuat B Chem 325:128768. https://doi.org/10.1016/j.snb.2020.128768

    Article  CAS  Google Scholar 

  28. Zhou K, Mousavi B, Luo ZX, Phatanasri S, Chaemchuen S, Verpoort F (2017) Characterization and properties of Zn/Co zeolitic imidazolate frameworks vs. ZIF–8 and ZIF–67. J Mater Chem A 5:952–957. https://doi.org/10.1039/c6ta07860e

    Article  CAS  Google Scholar 

  29. Yang LY, Hu LW, Zhao SJ, Zhao RL, Gu W, Jin TM (2019) Immobilization of glucose oxidase based on the sodium alginate–modified products of a functionalized metal organic framework and the application for one–pot analysis of glucose. J Coord Chem 72:428–437. https://doi.org/10.1080/00958972.2018.1564914

    Article  CAS  Google Scholar 

  30. Xia W, Zhu JH, Guo WH, An L, Xia DG, Zou RQ (2014) Well–defined carbon polyhedrons prepared from nano metal–organic frameworks for oxygen reduction. J Mater Chem A 2:11606–11613. https://doi.org/10.1039/c4ta01656d

    Article  CAS  Google Scholar 

  31. Rafiei S, Tangestaninejad S, Horcajada P, Moghadam M, Mirkhani V, Mohammadpoor-Baltork I, Kardanpour R, Zadehahmadi F (2018) Efficient biodiesel production using a lipase@ZIF–67 nanobioreactor. Chem Eng J 334:1233–1241. https://doi.org/10.1016/j.cej.2017.10.094

    Article  CAS  Google Scholar 

  32. Jin T, Li YL, Jing WJ, Li YC, Fan LZ, Li XH (2020) Cobalt–based metal organic frameworks: a highly active oxidase–mimicking nanozyme for fluorescence “turn–on” assays of biothiol. Chem Commun 56:659–662. https://doi.org/10.1039/c9cc06840f

    Article  CAS  Google Scholar 

  33. Yi XL, Dong WF, Zhang XD, Xie JX, Huang YM (2016) MIL–53(Fe) MOF–mediated catalytic chemiluminescence for sensitive detection of glucose. Anal Bioanal Chem 408:8805–8812. https://doi.org/10.1007/s00216-016-9681-y

    Article  CAS  PubMed  Google Scholar 

  34. Xue QT, Yi DZ, Zhong WJ, Dong MW, Cheng ZH, Yuan FL (2018) Fe3O4 and metal–organic framework MIL–101(Fe) composites catalyze luminol chemiluminescence for sensitively sensing hydrogen peroxide and glucose. Talanta 179:43–50. https://doi.org/10.1016/j.talanta.2017.10.049

    Article  CAS  Google Scholar 

  35. Mao XX, Lu YW, Zhang XD, Huang YM (2018) β–Cyclodextrin functionalization of metal–organic framework MOF–235 with excellent chemiluminescence activity for sensitive glucose biosensing. Talanta 188:161–167. https://doi.org/10.1016/j.talanta.2018.05.077

    Article  CAS  PubMed  Google Scholar 

  36. Luo FQ, Lin YL, Zheng LY, Lin XM, Chi YW (2015) Encapsulation of hemin in metal–organic frameworks for catalyzing the chemiluminescence reaction of the H2O2–luminol system and detecting glucose in the neutral condition. ACS Appl Mater Interfaces 7:11322–11329. https://doi.org/10.1021/acsami.5b01706

    Article  CAS  PubMed  Google Scholar 

  37. Li BX, Lan D, Zhang ZJ (2008) Chemiluminescence flow–through biosensor for glucose with eggshell membrane as enzyme immobilization platform. Anal Biochem 374:64–70. https://doi.org/10.1016/j.ab.2007.10.036

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

Financial support from the Natural Science Foundation of Shaanxi Province (Grant No. 2020JM-035) is greatly appreciated.

Author information

Authors and Affiliations

  1. School of Chemistry, Xi’an Jiaotong University, Xi’an 710049, China

    Xiaotong Xu, Yuyu Ma, Shujiang Ding & Yinhuan Li

Authors
  1. Xiaotong Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuyu Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shujiang Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yinhuan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yinhuan Li.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 473 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, X., Ma, Y., Ding, S. et al. Glucose oxidase@zinc-doped zeolitic imidazolate framework-67 as an effective cascade catalyst for one-step chemiluminescence sensing of glucose. Microchim Acta 188, 427 (2021). https://doi.org/10.1007/s00604-021-05096-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00604-021-05096-2

Keywords

Search

Navigation