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In situ controllable heterojunction conversion strategy driven by oriented paper-based fluid transfer for human immunoglobulin G detection

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Abstract

Mercury ions (Hg2+) mediating in situ heterojunction formation strategy based on spatially separated dual working areas was developed to achieve sensitive detection of human immunoglobulin G. To be specific, the complex of antibody, the silicon dioxide, and thymine-rich hairpin DNA were immobilized onto the antigen and antibody-modified electrodes, forming a special sandwich type where T-Hg2+-T structure could accommodate Hg2+. The zinc ions from zinc sulfide (ZnS) photoelectric materials were captured by Hg2+ to convert ZnS to zinc sulfide-mercuric sulfide nanocomposite. Such ion exchange approach with spatially separated working electrodes endowed the sensing platform with lower background interference and high selectivity, which also avoided damage of illumination on biomolecules. In addition, by regulating the ion recognition probe, the protocol could be extended to numerous other fields like clinical diagnosis, environmental monitoring, and public safety.

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Funding

The work was financially supported by the National Natural Science Foundation of China (21874055), the Taishan Scholars Program, the Project of “20 items of University” of Jinan (2018GXRC001), and Case-by-Case Project for Top Outstanding Talents of Jinan and the Excellent Youth Innovation Team in Universities of Shandong (2019KJC016).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People’s Republic of China

    Huihui Shi, Li Li & Jinghua Yu

  2. Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan, 250022, People’s Republic of China

    Lina Zhang

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  1. Huihui Shi
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  2. Li Li
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  4. Jinghua Yu
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Correspondence to Li Li or Jinghua Yu.

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Shi, H., Li, L., Zhang, L. et al. In situ controllable heterojunction conversion strategy driven by oriented paper-based fluid transfer for human immunoglobulin G detection. Microchim Acta 188, 373 (2021). https://doi.org/10.1007/s00604-021-05017-3

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