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Colorimetric sensing of chloride in sweat based on fluorescence wavelength shift via halide exchange of CsPbBr3 perovskite nanocrystals

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Abstract

Considering the high importance of the rapid detection of chloride ion (Cl−) in sweat for the diagnosis of fibrotic cysts, we have investigated the heterogeneous halide exchange between CsPbBr3 perovskite nanocrystals (PNCs) in n-hexane and Cl− in aqueous solution. The results show that CsPbBr3 PNCs could achieve fast halide exchange with Cl− in the aqueous phase under magnetic stirring at pH = 1, accompanied by a significant wavelength blue shift and vivid fluorescence color changes from green to blue. Therefore, a fluorescence wavelength shift-based colorimetric sensing of Cl− based on the halide exchange of CsPbBr3 PNCs has been developed to realize the rapid detection of Cl− in sweat. Compared with the conventional fluorescence intensity-based method, this method is of high convenience since the whole procedure could be achieved within 5 min without any sample pretreatment (even no dilution), demonstrating promising application prospects.

Fluorescence wavelength-shift based colorimetric sensing of chloride in sweat via halide exchange of CsPbBr3 perovskite nanocrystals

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Acknowledgments

We gratefully acknowledge the financial supports by the National Natural Science Foundation of China (No. 21675133,22004055), the Shenzhen Science and Technology Project (No. JCYJ20180306172823786), and the Training Program of the Outstanding Young Scientific Talents in Fujian (2018-47), Natural Science Foundation of Fujian Province of China (2020J05165).

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Author notes

  1. Feiming Li and Yufeng Feng contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou, 363000, People’s Republic of China

    Feiming Li

  2. The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, People’s Republic of China

    Yufeng Feng

  3. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361005, People’s Republic of China

    Yipeng Huang, Yimeng Zhu & Xi Chen

  4. Institute of Analytical Technology and Smart Instruments and College of Environment and Public Healthy, Xiamen Huaxia University, Xiamen, 361024, People’s Republic of China

    Qiuhong Yao & Guihua Huang

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  1. Feiming Li
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Correspondence to Xi Chen.

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Li, F., Feng, Y., Huang, Y. et al. Colorimetric sensing of chloride in sweat based on fluorescence wavelength shift via halide exchange of CsPbBr3 perovskite nanocrystals. Microchim Acta 188, 2 (2021). https://doi.org/10.1007/s00604-020-04653-5

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