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A ruthenium(IV) disulfide based non-enzymatic sensor for selective and sensitive amperometric determination of dopamine

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Abstract

An electrochemical dopamine (DA) sensor has been fabricated by modifying a glassy carbon electrode (GCE) with ruthenium disulfide (RuS2) nanoparticles (NPs). FESEM and TEM micrographs show the NPs to have an average size of ~45 nm. XRD, Raman and EDS, in turn, confirm the successful formation of cubic phased RuS2 NPs. The modified GCE displays has attractive features of merit that include (a) an ultra-low detection limit (73.8 nM), (b) fast response time (< 4 s), (c) a low oxidation potential (0.25 V vs. Ag|AgCl), (d) excellent reproducibility and stability, (e) an electrochemical sensitivity of 18.4 μA μM−1 cm−2 and 1.8 μA.μM−1.cm−2 in the linear ranges from 0.1–10 μM of DA (R2 = 0.97) and 10–80 μM of DA (R2 = 0.99), respectively. The sensor exhibits excellent specificity over potential interferents like ascorbic acid, glucose and uric acid. The superior performance of the sensor is attributed to its high electrical conductivity, large electro-active surface, and large numbers of exposed catalytically active sites resulting from the presence of unreacted sulfur atoms.

A ruthenium disulfide modified electrochemical sensor material was obtained by single-step hydrothermal synthesis. Sensitive and highly selective detection of dopamine is demonstrated.

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Acknowledgements

The authors acknowledge financial assistance from Department of Science and Technology (DST), Government of India, under INSPIRE Faculty Fellowship Grant # DST/INSPIRE/04/2014/015132 and Scientific and Engineering Research Board Grant SB/WEA-03/2017.

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  1. Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, 502285, India

    J. Deepika, Rinky Sha & Sushmee Badhulika

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  1. J. Deepika
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Correspondence to Sushmee Badhulika.

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J. Deepika and Rinky Sha equally contributed to this work

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Deepika, J., Sha, R. & Badhulika, S. A ruthenium(IV) disulfide based non-enzymatic sensor for selective and sensitive amperometric determination of dopamine. Microchim Acta 186, 480 (2019). https://doi.org/10.1007/s00604-019-3622-3

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