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Voltammetric dopamine sensor based on a gold electrode modified with reduced graphene oxide and Mn3O4 on gold nanoparticles

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Abstract

The authors describe an amperometric sensor for dopamine (DA) which has a working potential as low as +0.02 V (vs. SCE). It makes use of a nanocomposite consisting of reduced graphene oxide (rGO) and manganic manganous oxide (Mn3O4) in a film of Nafion on gold nanoparticles deposited on a gold electrode. The composite was characterized by X-ray powder diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FE-SEM). The electrochemical properties of the modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and amperometric methods. After method optimization, the amperogram displays a linear range extending from 1.0 μmol·L−1 to 1.45 mmol·L−1 with a limit of detection as low as 0.25 μmol·L−1 (at an S/N ratio of 3). The modified electrode was employed for the determination of DA in injection solution samples with satisfactory results.

Schematic of an electrochemical sensor based on a gold electrode (GE) sensitized with a nanocomposite consisting of reduced graphene oxide (rGO) and manganic manganous oxide (Mn3O4) in a film of Nafion supported gold nanoparticles (Au).

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Acknowledgements

The work was supported by the National Natural Science Foundation of China (No. 51672104 and No. 21675045), the Natural Science Foundation of Hunan Province (No. 2016JJ4071, No. 2017JJ2198) and the Foundation of Hunan Provincial Education Department (No.16B205 and No. 17C1148).

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Authors and Affiliations

  1. Hunan Provincal Key Laboratory for Ethnic Dong Medicine Research, Hunan University of Medicine, Huaihua, 418000, People’s Republic of China

    Zufu Yao

  2. Key Laboratory of Rare Earth Optoelectronic Materials & Devices, College of Chemistry and Materials Engineering, Huaihua University, Huaihua, 418000, People’s Republic of China

    Xin Yang, Feng Wu, Yangjian Hu & Yaqi Yang

  3. Department of Medical Cell Biology & Genetics, Hunan University of Medicine, Huaihua, 418000, People’s Republic of China

    Youya Niu

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  1. Zufu Yao
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  2. Xin Yang
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Correspondence to Xin Yang.

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Yao, Z., Yang, X., Niu, Y. et al. Voltammetric dopamine sensor based on a gold electrode modified with reduced graphene oxide and Mn3O4 on gold nanoparticles. Microchim Acta 184, 2081–2088 (2017). https://doi.org/10.1007/s00604-017-2210-7

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